The expanding roles of long non-coding RNAs in the regulation of cancer stem cells.
Cancer stem cells
Long non-coding RNAs
Tumorigenesis
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
07
11
2018
revised:
05
01
2019
accepted:
07
01
2019
pubmed:
11
1
2019
medline:
30
8
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
Long non-coding RNAs (lncRNAs) are a novel class of gene regulators playing multifaceted roles in physiological processes as well as pathological conditions such as cancer. Cancer stem cells (CSCs) are a small subset of tumor cells that constitute the origin and development of various malignant tumors. CSCs have been identified in a wide spectrum of human tumors and could act as a critical link underlying the processes of tumor metastasis and recurrence. Mounting evidence indicates that lncRNAs are aberrantly expressed in diverse CSCs and regulate CSC properties at different molecular levels. Here, we very briefly summarize the recent findings on the potential roles of lncRNAs in regulating various functions of CSCs, and elaborate on how can lncRNAs impact CSC properties via interacting with other macromolecules at the epigenetic, transcriptional, and post-transcriptional levels. This mini-review also highlights the understanding of the modular regulatory principles of lncRNA interactions in CSCs.
Identifiants
pubmed: 30630112
pii: S1357-2725(19)30003-2
doi: 10.1016/j.biocel.2019.01.003
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-20Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.