Personality Changes With Dementia From the Informant Perspective: New Data and Meta-Analysis.
Alzheimer's disease
Dementia
cognition-enhancing
conscientiousness
extraversion
mild cognitive impairment
neuroticism
personality
Journal
Journal of the American Medical Directors Association
ISSN: 1538-9375
Titre abrégé: J Am Med Dir Assoc
Pays: United States
ID NLM: 100893243
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
10
09
2018
revised:
02
11
2018
accepted:
03
11
2018
pubmed:
12
1
2019
medline:
27
6
2020
entrez:
12
1
2019
Statut:
ppublish
Résumé
To examine changes in personality in individuals with mild cognitive impairment (MCI) or dementia as observed by family members using both new data and a meta-analysis with the published literature. Current and retrospective personality assessments of individuals with dementia by family informants. PubMed was searched for studies with a similar design and a forward citation tracking was conducted using Google Scholar in June 2018. Results from a new sample and from published studies were combined in a random effect meta-analysis. Family members of older adults with MCI or dementia. The 5 major dimensions (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and facets of personality were assessed with NEO Personality Inventory questionnaires. The new sample (n = 50) and meta-analysis (18 samples; n = 542) found consistent shifts in personality from the premorbid to current state in patients with cognitive impairment. The largest changes (>1 standard deviation) were declines in conscientiousness (particularly for the facets of self-discipline and competence) and extraversion (decreased energy and assertiveness), as well as increases in neuroticism (increased vulnerability to stress). The new sample suggested that personality changes were larger in individuals taking cognition-enhancing medications (cholinesterase inhibitors or memantine). More recent studies and those that examined individuals with MCI found smaller effects. Consistent with the clinical criteria for the diagnosis of dementia, the new study and meta-analysis found replicable evidence for large changes in personality among individuals with dementia. Future research should examine whether there are different patterns of personality changes across etiologies of dementia to inform differential diagnosis and treatments. Prospective, repeated assessments of personality using both self- and informant-reports are essential to clarify the temporal evolution of personality change across the preclinical, prodromal, and clinical phases of dementia.
Identifiants
pubmed: 30630729
pii: S1525-8610(18)30636-4
doi: 10.1016/j.jamda.2018.11.004
pmc: PMC6432780
mid: NIHMS1513115
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-137Subventions
Organisme : NIA NIH HHS
ID : R01 AG053297
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG057917
Pays : United States
Informations de copyright
Copyright © 2018 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.
Références
Exp Aging Res. 1995 Jul-Sep;21(3):295-314
pubmed: 7493597
Dialogues Clin Neurosci. 2003 Mar;5(1):101-8
pubmed: 22034141
QJM. 2016 May;109(5):301-2
pubmed: 26261354
Cochrane Database Syst Rev. 2006 Jan 25;(1):CD005593
pubmed: 16437532
JAMA Psychiatry. 2017 Dec 1;74(12):1259-1265
pubmed: 28975188
BMJ. 2015 Mar 02;350:h369
pubmed: 25731881
J Am Geriatr Soc. 2018 Apr;66(4):671-678
pubmed: 29341070
Alzheimer Dis Assoc Disord. 2013 Jul-Sep;27(3):258-64
pubmed: 23060360
Psychol Aging. 1993 Dec;8(4):475-80
pubmed: 8292276
Alzheimer Dis Assoc Disord. 1991 Winter;5(4):240-50
pubmed: 1781966
Alzheimer Dis Assoc Disord. 1994 Fall;8(3):166-76
pubmed: 7986486
Assessment. 2018 Apr;25(3):336-347
pubmed: 29214858
Psychol Aging. 1994 Sep;9(3):464-6
pubmed: 7999331
J Alzheimers Dis. 2019;67(2):707-713
pubmed: 30636733
Curr Biol. 2006 Nov 7;16(21):R906-10
pubmed: 17084683
Aging Ment Health. 2010 Jul;14(5):503-15
pubmed: 20480417
Int J Geriatr Psychiatry. 2013 Mar;28(3):276-83
pubmed: 22552913
Int J Geriatr Psychiatry. 2015 Sep;30(9):985-93
pubmed: 25581393
J Pers Soc Psychol. 2005 Mar;88(3):547-61
pubmed: 15740445
J Am Med Dir Assoc. 2018 Mar;19(3):276.e1-276.e9
pubmed: 29477773
Med Care. 2009 Feb;47(2):191-8
pubmed: 19169120
J Alzheimers Dis. 2018;62(2):773-787
pubmed: 29480186
Dement Geriatr Cogn Disord. 2013;36(5-6):329-39
pubmed: 24022337
J Am Med Dir Assoc. 2018 Jul;19(7):627-632
pubmed: 29146222
J Pers. 1992 Jun;60(2):175-215
pubmed: 1635039
Dement Geriatr Cogn Disord. 2013;35(1-2):87-97
pubmed: 23364170
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Int J Geriatr Psychiatry. 2011 Oct;26(10):1019-29
pubmed: 21905097
Arch Neurol. 1992 May;49(5):486-91
pubmed: 1580810
Can J Psychiatry. 2011 Jul;56(7):408-17
pubmed: 21835104
Int J Geriatr Psychiatry. 2018 Mar;33(3):489-494
pubmed: 28869657
Pers Soc Psychol Bull. 2006 Aug;32(8):999-1009
pubmed: 16861305
Pers Soc Psychol Rev. 2011 Feb;15(1):28-50
pubmed: 20435807
J Gerontol Nurs. 1997 Feb;23(2):21-30
pubmed: 9086978
Alzheimer Dis Assoc Disord. 2000 Jan-Mar;14(1):11-9
pubmed: 10718200
Alzheimer Dis Assoc Disord. 2014 Jul-Sep;28(3):261-8
pubmed: 24614269
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Personal Disord. 2019 Jan;10(1):4-12
pubmed: 30604979
J Gerontol B Psychol Sci Soc Sci. 2020 Jan 14;75(2):251-262
pubmed: 29608748
Am J Geriatr Psychiatry. 2007 Mar;15(3):202-13
pubmed: 17322133