Clustering of Tau fibrils impairs the synaptic composition of α3-Na
cross‐talk of pathogenic proteins
misfolding disease
protein aggregation and clustering
single‐particle tracking
tauopathies
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
21
05
2018
revised:
29
11
2018
accepted:
30
11
2018
pubmed:
12
1
2019
medline:
7
1
2020
entrez:
12
1
2019
Statut:
ppublish
Résumé
Tau assemblies have prion-like properties: they propagate from one neuron to another and amplify by seeding the aggregation of endogenous Tau. Although key in prion-like propagation, the binding of exogenous Tau assemblies to the plasma membrane of naïve neurons is not understood. We report that fibrillar Tau forms clusters at the plasma membrane following lateral diffusion. We found that the fibrils interact with the Na
Identifiants
pubmed: 30630857
pii: embj.201899871
doi: 10.15252/embj.201899871
pmc: PMC6356061
pii:
doi:
Substances chimiques
Amyloid
0
Receptors, AMPA
0
alpha-Synuclein
0
tau Proteins
0
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
sodium potassium ATPase alpha3 subunit, human
EC 7.2.2.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
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