Secreted amyloid-β precursor protein functions as a GABA
Amino Acid Sequence
Amyloid beta-Protein Precursor
/ physiology
Animals
Cells, Cultured
HEK293 Cells
Hippocampus
/ physiology
Humans
Male
Membrane Proteins
/ physiology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Neuronal Plasticity
Neurons
/ cytology
Peptides
Protein Binding
Protein Domains
Proteomics
Receptors, GABA-A
/ physiology
Synapses
/ physiology
Synaptic Transmission
Synaptic Vesicles
/ physiology
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
11 01 2019
11 01 2019
Historique:
received:
31
07
2017
revised:
30
09
2018
accepted:
14
11
2018
entrez:
12
1
2019
pubmed:
12
1
2019
medline:
30
7
2019
Statut:
ppublish
Résumé
Amyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor for secreted APP (sAPP). Here we show that the sAPP extension domain directly bound the sushi 1 domain specific to the γ-aminobutyric acid type B receptor subunit 1a (GABA
Identifiants
pubmed: 30630900
pii: 363/6423/eaao4827
doi: 10.1126/science.aao4827
pmc: PMC6366617
mid: NIHMS1009544
pii:
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
Gabrb1 protein, mouse
0
Membrane Proteins
0
Peptides
0
Receptors, GABA-A
0
Srpx protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Subventions
Organisme : European Research Council
ID : 311083
Pays : International
Organisme : NIA NIH HHS
ID : R01 AG061787
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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