Inhibition of HGF/MET signaling decreases overall tumor burden and blocks malignant conversion in Tpl2-related skin cancer.
Journal
Oncogenesis
ISSN: 2157-9024
Titre abrégé: Oncogenesis
Pays: United States
ID NLM: 101580004
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
received:
11
08
2018
accepted:
03
12
2018
revised:
16
11
2018
entrez:
12
1
2019
pubmed:
12
1
2019
medline:
12
1
2019
Statut:
epublish
Résumé
Tumor progression locus 2 (Tpl2) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family of serine/threonine kinases. Deletion of the Tpl2 gene is associated with a significantly higher number of papillomas and cutaneous squamous cell carcinomas (cSCCs). Overexpression of hepatocyte growth factor (HGF) and its receptor MET is abundant in cSCC and can lead to increased proliferation, migration, invasion or resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. The aim of this study was to address whether the increased tumor burden in Tpl2
Identifiants
pubmed: 30631034
doi: 10.1038/s41389-018-0109-8
pii: 10.1038/s41389-018-0109-8
pmc: PMC6328619
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1Subventions
Organisme : NCI NIH HHS
ID : R15 CA152907
Pays : United States
Organisme : NCI NIH HHS
ID : UA5 CA152907
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 2R15CA152907-02
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 1UA5CA152907-01A1
Références
Oncogene. 1999 Sep 2;18(35):4968-73
pubmed: 10490831
J Virol. 2002 May;76(9):4567-79
pubmed: 11932422
Cancer Res. 2002 Jun 15;62(12):3395-401
pubmed: 12067981
Cancer Res. 1992 Jun 1;52(11):3145-56
pubmed: 1375535
J Biol Chem. 1992 Dec 15;267(35):24917-20
pubmed: 1459995
Mol Cancer. 2004 Dec 03;3(1):34
pubmed: 15575964
Breast Cancer Res Treat. 2005 May;91(1):95-102
pubmed: 15868436
Cancer Res. 2005 Oct 15;65(20):9304-11
pubmed: 16230392
Eur J Cancer. 2006 Apr;42(6):751-9
pubmed: 16530403
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2987-92
pubmed: 18287049
Nat Protoc. 2008;3(5):799-810
pubmed: 18451788
Mol Cancer Res. 2008 Oct;6(10):1521-33
pubmed: 18922968
Nat Protoc. 2009;4(9):1350-62
pubmed: 19713956
Curr Cancer Drug Targets. 2010 Dec;10(8):849-57
pubmed: 20718708
Oncogene. 2011 Jan 27;30(4):389-97
pubmed: 20935675
Nature. 2010 Dec 16;468(7326):968-72
pubmed: 21107320
Oncogene. 2011 Apr 28;30(17):2003-16
pubmed: 21217780
Ann Dermatol. 2011 Feb;23(1):33-8
pubmed: 21738360
Clin Cancer Res. 2011 Nov 15;17(22):7127-38
pubmed: 21918175
Hepatology. 2012 Apr;55(4):1215-26
pubmed: 22095660
Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S37-50
pubmed: 22128287
N Engl J Med. 2012 Nov;367(18):1694-703
pubmed: 23020132
J Clin Invest. 2012 Nov;122(11):4231-42
pubmed: 23064365
J Skin Cancer. 2012;2012:249063
pubmed: 23326666
J Am Acad Dermatol. 2013 Jun;68(6):957-66
pubmed: 23375456
PLoS One. 2013;8(2):e56212
pubmed: 23457529
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1470-9
pubmed: 23533274
Cold Spring Harb Perspect Biol. 2013 Jul 01;5(7):null
pubmed: 23818496
Carcinogenesis. 2013 Dec;34(12):2789-98
pubmed: 24067898
Mol Cancer. 2014 Aug 07;13:185
pubmed: 25098767
BMC Cancer. 2015 Feb 19;15:71
pubmed: 25884642
World J Gastroenterol. 2015 May 14;21(18):5445-53
pubmed: 25987766
J Pathol. 2015 Nov;237(3):319-29
pubmed: 26108200
Oncol Rep. 2015 Oct;34(4):2179-87
pubmed: 26259977
Clin Cancer Res. 2016 Apr 1;22(7):1592-602
pubmed: 26673799
Cancer Res. 2016 Mar 15;76(6):1591-602
pubmed: 26825170
Sci Signal. 2016 Jun 21;9(433):ra62
pubmed: 27330189
Cancer Res. 2016 Nov 15;76(22):6712-6722
pubmed: 27503930
Cancer Sci. 2016 Dec;107(12):1867-1876
pubmed: 27779808
Clin Lung Cancer. 2017 May;18(3):281-285
pubmed: 28038979
Cancer Sci. 2017 Mar;108(3):296-307
pubmed: 28064454
Mol Oncol. 2017 Mar;11(3):320-334
pubmed: 28164434
Biochem Soc Trans. 2017 Aug 15;45(4):855-870
pubmed: 28673936
Trends Cancer. 2017 Jan;3(1):56-71
pubmed: 28718426
J Biochem. 1995 Feb;117(2):458-64
pubmed: 7608139
J Biol Chem. 1994 Feb 11;269(6):4152-60
pubmed: 8307976
EMBO J. 1996 Feb 15;15(4):817-26
pubmed: 8631303
Genes Dev. 1997 Mar 15;11(6):688-700
pubmed: 9087424