Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

Bacterial Proteins / metabolism Chromosomal Instability / physiology DNA Damage / genetics DNA Repair / physiology DNA Replication / physiology DNA-Binding Proteins / metabolism Escherichia coli / metabolism Genomic Instability Humans Membrane Transport Proteins / physiology Mutagenesis Mutation Transcription Factors / metabolism
DNA damage response DNA double-strand breaks DNMT1 Escherichia coli cancer evolution genome instability human cells microbial cancer models replication fork reversal

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
10 01 2019
Historique:
received: 07 01 2018
revised: 05 09 2018
accepted: 05 12 2018
entrez: 12 1 2019
pubmed: 12 1 2019
medline: 14 11 2019
Statut: ppublish

Résumé

DNA damage provokes mutations and cancer and results from external carcinogens or endogenous cellular processes. However, the intrinsic instigators of endogenous DNA damage are poorly understood. Here, we identify proteins that promote endogenous DNA damage when overproduced: the DNA "damage-up" proteins (DDPs). We discover a large network of DDPs in Escherichia coli and deconvolute them into six function clusters, demonstrating DDP mechanisms in three: reactive oxygen increase by transmembrane transporters, chromosome loss by replisome binding, and replication stalling by transcription factors. Their 284 human homologs are over-represented among known cancer drivers, and their RNAs in tumors predict heavy mutagenesis and a poor prognosis. Half of the tested human homologs promote DNA damage and mutation when overproduced in human cells, with DNA damage-elevating mechanisms like those in E. coli. Our work identifies networks of DDPs that provoke endogenous DNA damage and may reveal DNA damage-associated functions of many human known and newly implicated cancer-promoting proteins.

Identifiants

DOI: 10.1016/j.cell.2018.12.008 PMID: 30633903 PMC: PMC6344048
pubmed: 30633903
pii: S0092-8674(18)31622-2
doi: 10.1016/j.cell.2018.12.008
pmc: PMC6344048
mid: NIHMS1516482
pii:
doi:

Substances chimiques

Bacterial Proteins 0
DNA-Binding Proteins 0
Membrane Transport Proteins 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

127-143.e24

Subventions

Organisme : NCI NIH HHS
ID : R01 CA198279
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM089636
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102679
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007495
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD007495
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056338
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036211
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122598
Pays : United States
Organisme : NCI NIH HHS
ID : DP1 CA174424
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA201268
Pays : United States
Organisme : NIH HHS
ID : DP2 OD008371
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA168394
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217842
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA175486
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM088653
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008231
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR024574
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM106373
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA209851
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD007495
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Jun Xia (J)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.

Li-Ya Chiu (LY)

Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.

Ralf B Nehring (RB)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

María Angélica Bravo Núñez (MA)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Qian Mei (Q)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Systems, Synthetic and Physical Biology Program, Rice University, Houston, TX 77030, USA.

Mercedes Perez (M)

Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.

Yin Zhai (Y)

Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Devon M Fitzgerald (DM)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

John P Pribis (JP)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.

Yumeng Wang (Y)

Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Chenyue W Hu (CW)

Department of Bioengineering, Rice University, Houston, TX 77030, USA.

Reid T Powell (RT)

Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.

Sandra A LaBonte (SA)

Department of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX 77843, USA.

Ali Jalali (A)

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.

Meztli L Matadamas Guzmán (ML)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Alfred M Lentzsch (AM)

Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.

Adam T Szafran (AT)

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Mohan C Joshi (MC)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Megan Richters (M)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Janet L Gibson (JL)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Ryan L Frisch (RL)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

P J Hastings (PJ)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

David Bates (D)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Christine Queitsch (C)

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Susan G Hilsenbeck (SG)

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Cristian Coarfa (C)

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

James C Hu (JC)

Department of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX 77843, USA.

Deborah A Siegele (DA)

Department of Biology, Texas A&M University, College Station, TX 77843, USA.

Kenneth L Scott (KL)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.

Han Liang (H)

Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Michael A Mancini (MA)

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Christophe Herman (C)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: herman@bcm.edu.

Kyle M Miller (KM)

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Biosciences, LIVESTRONG Cancer Institute of the Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: kyle.miller@austin.utexas.edu.

Susan M Rosenberg (SM)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Systems, Synthetic and Physical Biology Program, Rice University, Houston, TX 77030, USA. Electronic address: smr@bcm.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des chromosomes › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Bacteria-to-Human Protein Networks Reveal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Bacteria-to-Human Protein Networks Reveal...