Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention.

Animals Attention / physiology Butylamines / antagonists & inhibitors Cells, Cultured Dopamine / metabolism Dose-Response Relationship, Drug Male Motor Activity / drug effects Norepinephrine / metabolism Norepinephrine Plasma Membrane Transport Proteins / antagonists & inhibitors Prazosin / pharmacology Prefrontal Cortex / metabolism Raclopride / pharmacology Rats Receptors, Dopamine D3 / agonists
Catecholamine Dopamine D3R agonist Dopamine transporter Executive function Locomotor activity Methylphenidate Microdialysis Norepinephrine transporter inhibitor Sustained attention

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
04 2019
Historique:
received: 18 06 2018
revised: 28 12 2018
accepted: 06 01 2019
pubmed: 12 1 2019
medline: 28 12 2019
entrez: 12 1 2019
Statut: ppublish

Résumé

Catecholamine transmitters dopamine (DA) and norepinephrine (NE) regulate prefrontal cortical (PFC) circuit activity and PFC-mediated executive functions. Accordingly, pharmacological agents that influence catecholamine neurotransmission exert prominent effects on cognition. Many such agents are used clinically to treat attention disorders. For example, methylphenidate blocks DA and NE reuptake and is the leading choice for attention deficit hyperactivity disorder (ADHD) treatment. Recently, we have designed SK609 - a selective small molecule agonist of the DA D3 receptor (D3R). In this study, we further characterized SK609's ability to selectively inhibit the reuptake of NE by NE transporters (NET). Our results indicate SK609 selectively inhibits NET with a K

Identifiants

DOI: 10.1016/j.neuropharm.2019.01.003 PMID: 30633928 PMC: PMC6424628
pubmed: 30633928
pii: S0028-3908(19)30002-4
doi: 10.1016/j.neuropharm.2019.01.003
pmc: PMC6424628
mid: NIHMS1006809
pii:
doi:

Substances chimiques

4-(2-chlorophenyl)butan-2-amine 0
Butylamines 0
Norepinephrine Plasma Membrane Transport Proteins 0
Receptors, Dopamine D3 0
Raclopride 430K3SOZ7G
Dopamine VTD58H1Z2X
Norepinephrine X4W3ENH1CV
Prazosin XM03YJ541D

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

178-188

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA017960
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA019676
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA031900
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106912
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

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Auteurs

Courtney A Marshall (CA)

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.

Zachary D Brodnik (ZD)

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.

Ole V Mortensen (OV)

Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA.

Maarten E A Reith (MEA)

Department of Psychiatry and of Biochemistry and Molecular Pharmacology, New York University Langone Medical Center, New York City, NY, USA.

Jed S Shumsky (JS)

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.

Barry D Waterhouse (BD)

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA; Department of Cell Biology and Neurscience, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

Rodrigo A España (RA)

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.

Sandhya Kortagere (S)

Department of Microbiology and Immunology, Institute for Molecular Medicine, Drexel University College of Medicine, Philadelphia, PA, USA; Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: sk673@drexel.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Phénomènes psychologiques › Attention › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Butanes › Butylamines › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Cellules › Cellules cultivées › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la norépinéphrine › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Prazosine › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Chloro-benzoates › Raclopride › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Selective activation of Dopamine D3 receptors...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur D2 de la dopamine › Récepteur D3 de la dopamine › Selective activation of Dopamine D3 receptors...