Strategies for reconstructing the limbal stem cell niche.
Corneal limbus
Epithelial cell
Extracellular matrix
Limbal epithelial stem cell deficiency
Mesenchymal stem cell
Regenerative medicine
Stem cell niche
Journal
The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
03
07
2018
revised:
21
10
2018
accepted:
07
01
2019
pubmed:
12
1
2019
medline:
20
8
2020
entrez:
12
1
2019
Statut:
ppublish
Résumé
The epithelial cell layer that covers the surface of the cornea provides a protective barrier while maintaining corneal transparency. The rapid and effective turnover of these epithelial cells depends, in part, on the limbal epithelial stem cells (LESCs) located in a specialized microenvironment known as the limbal niche. Many disorders affecting the regeneration of the corneal epithelium are related to deficiency and/or dysfunction of LESCs and the limbal niche. Current approaches for regenerating the corneal epithelium following significant injuries such as burns and inflammatory attacks are primarily aimed at repopulating the LESCs. This review summarizes and assesses the clinical feasibility and efficacy of current and emerging approaches for reconstruction of the limbal niche. In particular, the application of mesenchymal stem cells along with appropriate biological scaffolds appear to be promising strategies for long-term revitalization of the limbal niche.
Identifiants
pubmed: 30633966
pii: S1542-0124(18)30209-X
doi: 10.1016/j.jtos.2019.01.002
pmc: PMC6529262
mid: NIHMS1518809
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
230-240Subventions
Organisme : NEI NIH HHS
ID : K12 EY021475
Pays : United States
Organisme : NEI NIH HHS
ID : L30 EY017793
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY001792
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024349
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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