Obesity, Leptin and Breast Cancer: Epidemiological Evidence and Proposed Mechanisms.
adipokines
adiponectin
breast cancer
estrogens
inflammation
insulin/insulin-like growth factor I
leptin
obesity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
09 Jan 2019
09 Jan 2019
Historique:
received:
07
11
2018
revised:
20
12
2018
accepted:
08
01
2019
entrez:
13
1
2019
pubmed:
13
1
2019
medline:
13
1
2019
Statut:
epublish
Résumé
The prevalence of obesity has been steadily increasing over the past few decades in several developed and developing countries, with resultant hazardous health implications. Substantial epidemiological evidence has shown that excessive adiposity strongly influences risk, prognosis, and progression of various malignancies, including breast cancer. Indeed, it is now well recognized that obesity is a complex physiologic state associated with multiple molecular changes capable of modulating the behavior of breast tumor cells as well of the surrounding microenvironment. Particularly, insulin resistance, hyperactivation of insulin-like growth factor pathways, and increased levels of estrogen due to aromatization by the adipose tissue, inflammatory cytokines, and adipokines contribute to breast cancerogenesis. Among adipokines, leptin, whose circulating levels increase proportionally to total adipose tissue mass, has been identified as a key member of the molecular network in obesity. This review summarizes the current knowledge on the epidemiological link existing between obesity and breast cancer and outlines the molecular mechanisms underlying this connection. The multifaceted role of the obesity adipokine leptin in this respect is also discussed.
Identifiants
pubmed: 30634494
pii: cancers11010062
doi: 10.3390/cancers11010062
pmc: PMC6356310
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : AIRC - Italian Association for Cancer Research
ID : IG#11595 to S. Andò; MFAG#16899 to I. Barone
Références
Am J Epidemiol. 2000 Sep 15;152(6):514-27
pubmed: 10997541
Cancer Lett. 2001 Jan 26;162(2):155-60
pubmed: 11146220
J Clin Oncol. 2001 Jun 15;19(12):3111-6
pubmed: 11408508
J Clin Oncol. 2002 Jan 1;20(1):42-51
pubmed: 11773152
Breast Cancer Res. 2002;4(6):240-3
pubmed: 12473170
Breast Cancer Res Treat. 2003 Feb;77(3):205-15
pubmed: 12602920
J Biol Chem. 2003 Aug 1;278(31):28668-76
pubmed: 12734209
J Natl Cancer Inst. 2003 Aug 20;95(16):1218-26
pubmed: 12928347
EMBO J. 2003 Oct 1;22(19):5102-14
pubmed: 14517248
J Natl Cancer Inst. 2003 Oct 1;95(19):1467-76
pubmed: 14519753
Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):1053-60
pubmed: 14578142
Clin Cancer Res. 2003 Nov 15;9(15):5699-704
pubmed: 14654554
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Exp Biol Med (Maywood). 2004 Feb;229(2):182-93
pubmed: 14734797
Eur J Endocrinol. 2004 Feb;150(2):161-71
pubmed: 14763914
J Biol Chem. 2004 May 7;279(19):19908-15
pubmed: 14985328
J Clin Endocrinol Metab. 2004 Mar;89(3):1102-7
pubmed: 15001594
Cancer Causes Control. 2004 Apr;15(3):305-11
pubmed: 15090725
Clin Cancer Res. 2004 Jul 1;10(13):4325-31
pubmed: 15240518
Int J Cancer. 2004 Sep 20;111(5):762-71
pubmed: 15252848
Clin Cancer Res. 2004 Oct 1;10(19):6466-75
pubmed: 15475434
J Clin Oncol. 2005 Feb 1;23(4):774-82
pubmed: 15681521
Arch Intern Med. 2005 Jun 13;165(11):1267-73
pubmed: 15956006
Cancer Causes Control. 2005 Jun;16(5):561-72
pubmed: 15986111
Pharmacol Rev. 2005 Sep;57(3):359-83
pubmed: 16109840
J Lipid Res. 2005 Nov;46(11):2347-55
pubmed: 16150820
Lancet. 2005 Sep 24-30;366(9491):1108-10
pubmed: 16182899
Int J Cancer. 2006 Mar 15;118(6):1414-9
pubmed: 16206269
J Steroid Biochem Mol Biol. 2005 Dec;97(5):441-50
pubmed: 16249080
Lancet. 2005 Nov 19;366(9499):1784-93
pubmed: 16298215
Arch Pharm Res. 2005 Nov;28(11):1263-9
pubmed: 16350853
Clin Cancer Res. 2006 Mar 1;12(5):1447-53
pubmed: 16533767
Int J Cancer. 2006 Aug 1;119(3):659-67
pubmed: 16572422
Annu Rev Biochem. 2006;75:137-63
pubmed: 16756488
Breast Cancer Res. 2006;8(4):R39
pubmed: 16846528
Obesity (Silver Spring). 2006 Sep;14(9):1662-77
pubmed: 17030978
Obesity (Silver Spring). 2006 Nov;14(11):1940-8
pubmed: 17135609
Clin Cancer Res. 2006 Dec 1;12(23):7063-70
pubmed: 17145829
Cancer Res. 2006 Dec 1;66(23):11462-70
pubmed: 17145894
J Clin Invest. 2007 Jan;117(1):175-84
pubmed: 17200717
J Clin Endocrinol Metab. 2007 Apr;92(4):1510-6
pubmed: 17213279
Cancer Res. 2007 Apr 1;67(7):3412-21
pubmed: 17409452
J Clin Endocrinol Metab. 2007 Jul;92(7):2468-73
pubmed: 17440019
Cancer Res. 2007 Sep 15;67(18):8914-22
pubmed: 17875734
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16158-63
pubmed: 17911267
BMJ. 2007 Dec 1;335(7630):1134
pubmed: 17986716
Breast Cancer Res Treat. 2008 Dec;112(3):405-10
pubmed: 18163210
Br J Cancer. 2008 Jan 29;98(2):370-9
pubmed: 18182989
J Surg Res. 2008 Sep;149(1):9-14
pubmed: 18262553
Lancet. 2008 Feb 16;371(9612):569-78
pubmed: 18280327
Oncol Rep. 2008 Apr;19(4):905-11
pubmed: 18357374
Med Sci Sports Exerc. 2008 Jul;40(7 Suppl):S537-43
pubmed: 18562971
Oncol Rep. 2008 Oct;20(4):971-7
pubmed: 18813842
BMC Cancer. 2008 Oct 22;8:305
pubmed: 18945363
Int J Cancer. 2009 Feb 1;124(3):698-712
pubmed: 18988226
Cancer Res. 2008 Dec 1;68(23):9712-22
pubmed: 19047149
Cancer Res. 2008 Dec 15;68(24):10238-46
pubmed: 19074892
J Natl Cancer Inst. 2009 Jan 7;101(1):48-60
pubmed: 19116382
Fertil Steril. 2010 Apr;93(6):2004-11
pubmed: 19185860
J Clin Oncol. 2009 Jul 20;27(21):3437-44
pubmed: 19470939
Oncogene. 2009 Jul 30;28(30):2710-22
pubmed: 19483731
Mol Endocrinol. 2009 Oct;23(10):1634-45
pubmed: 19556341
Med Oncol. 2011 Sep;28(3):753-65
pubmed: 20411366
Clin Cancer Res. 2010 May 15;16(10):2702-8
pubmed: 20427689
Lancet Oncol. 2010 Jun;11(6):530-42
pubmed: 20472501
J Clin Oncol. 2010 Jul 20;28(21):3411-5
pubmed: 20547990
Breast Cancer Res Treat. 2010 Oct;123(3):627-35
pubmed: 20571870
Breast Cancer Res Treat. 2010 Oct;123(3):641-9
pubmed: 20711809
Diabetes Care. 2011 Jan;34(1):210-5
pubmed: 20937689
Am J Pathol. 2010 Dec;177(6):3133-44
pubmed: 21056997
Curr Oncol Rep. 2011 Feb;13(1):71-6
pubmed: 21080117
J Clin Oncol. 2011 Jan 1;29(1):32-9
pubmed: 21115858
Radiother Oncol. 2011 Aug;100(2):236-40
pubmed: 21296441
Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):454-63
pubmed: 21364029
Breast Cancer Res. 2011 Mar 30;13(2):R34
pubmed: 21450081
Qual Health Res. 2011 Sep;21(9):1191-204
pubmed: 21508251
Endocr Relat Cancer. 2011 Jul 01;18(4):413-28
pubmed: 21555376
J Clin Oncol. 2011 Jul 1;29(19):2653-9
pubmed: 21555684
Am J Clin Nutr. 2011 Jul;94(1):95-103
pubmed: 21613554
Endocr Relat Cancer. 2011 Jul 11;18(4):491-503
pubmed: 21636700
PLoS One. 2011;6(6):e21467
pubmed: 21731759
J Breast Cancer. 2011 Jun;14(2):96-103
pubmed: 21847403
Breast Cancer Res Treat. 2012 Jan;131(2):637-43
pubmed: 21935600
Am J Prev Med. 2011 Oct;41(4):366-75
pubmed: 21961463
Nat Rev Endocrinol. 2011 Nov 15;8(5):263-75
pubmed: 22083089
Trends Endocrinol Metab. 2012 Feb;23(2):83-9
pubmed: 22169755
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):829-34
pubmed: 22207628
Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):821-8
pubmed: 22208973
Cancer Res. 2012 Mar 15;72(6):1416-27
pubmed: 22282662
Biochim Biophys Acta. 2012 Apr;1825(2):207-22
pubmed: 22289780
Cancer Prev Res (Phila). 2012 Apr;5(4):583-92
pubmed: 22318751
J Clin Oncol. 2012 May 1;30(13):1553-61
pubmed: 22473167
Endocr Rev. 2012 Aug;33(4):547-94
pubmed: 22547160
Breast Cancer Res Treat. 2012 Jul;134(2):769-81
pubmed: 22562122
Cancer Discov. 2012 Apr;2(4):356-65
pubmed: 22576212
Breast Cancer Res Treat. 2012 Oct;135(3):647-54
pubmed: 22864804
Metabolism. 2013 Jan;62(1):127-36
pubmed: 22898251
Cancer Radiother. 2012 Sep;16(5-6):462-9
pubmed: 22925491
Endocrinology. 2012 Nov;153(11):5157-66
pubmed: 22962253
J Clin Oncol. 2012 Nov 10;30(32):3967-75
pubmed: 23045588
Annu Rev Med. 2013;64:45-57
pubmed: 23121183
Med Sci Sports Exerc. 2013 Apr;45(4):607-14
pubmed: 23190588
Mol Oncol. 2013 Jun;7(3):379-91
pubmed: 23228483
Diabetes Metab Res Rev. 2013 May;29(4):285-95
pubmed: 23390053
Cancer Causes Control. 2013 May;24(5):873-83
pubmed: 23408243
Lancet Oncol. 2013 May;14(6):500-15
pubmed: 23540561
Anticancer Res. 2013 Apr;33(4):1595-602
pubmed: 23564803
Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):756-64
pubmed: 23652373
PLoS One. 2013 Jun 27;8(6):e67349
pubmed: 23826274
Nat Rev Clin Oncol. 2013 Aug;10(8):451-9
pubmed: 23856744
Prev Med. 2013 Nov;57(5):525-32
pubmed: 23859929
Lancet Oncol. 2013 Sep;14(10):1009-19
pubmed: 23890780
J Am Coll Surg. 2013 Oct;217(4):656-64
pubmed: 23891077
Clin Cancer Res. 2013 Nov 15;19(22):6074-83
pubmed: 23958744
J Natl Cancer Inst. 2013 Sep 18;105(18):1373-84
pubmed: 24046390
Plast Reconstr Surg. 2013 Oct;132(4):750-61
pubmed: 24076667
Int J Cancer. 2014 Apr 15;134(8):1947-57
pubmed: 24155248
Curr Breast Cancer Rep. 2013 Sep;5(3):null
pubmed: 24265860
Lancet. 2014 Mar 15;383(9921):970-83
pubmed: 24269108
Cell Cycle. 2014;13(4):553-64
pubmed: 24335340
Epidemiol Rev. 2014;36:114-36
pubmed: 24375928
Cancer. 2014 May 15;120(10):1548-56
pubmed: 24500704
Cancer Causes Control. 2014 Apr;25(4):533-9
pubmed: 24504436
Plast Reconstr Surg. 2014 Mar;133(3):263e-273e
pubmed: 24572870
Cancer Causes Control. 2014 Jun;25(6):737-45
pubmed: 24715420
Int J Epidemiol. 2014 Aug;43(4):1226-36
pubmed: 24737805
Ann Oncol. 2014 Oct;25(10):1901-14
pubmed: 24769692
Cell. 2014 May 22;157(5):1013-22
pubmed: 24855941
Lancet. 2014 Aug 30;384(9945):766-81
pubmed: 24880830
J Natl Cancer Inst. 2014 Jun 23;106(7):null
pubmed: 24957076
Mol Cell Endocrinol. 2014 Aug 25;394(1-2):80-7
pubmed: 25011057
Lancet. 2014 Aug 30;384(9945):755-65
pubmed: 25129328
Med Sci Sports Exerc. 2015 May;47(5):896-904
pubmed: 25160845
Breast Cancer Res Treat. 2014 Oct;147(3):463-71
pubmed: 25164973
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):138-47
pubmed: 25352526
Annu Rev Med. 2015;66:281-96
pubmed: 25423596
Nutr Res. 2015 Jan;35(1):7-13
pubmed: 25453541
Front Oncol. 2014 Nov 26;4:340
pubmed: 25505738
FASEB J. 2015 May;29(5):2150-60
pubmed: 25657113
Cancer Prev Res (Phila). 2015 May;8(5):349-58
pubmed: 25720743
J Cell Mol Med. 2015 May;19(5):1122-32
pubmed: 25721149
Mol Cancer. 2015 Feb 15;14:43
pubmed: 25743390
Acta Oncol. 2015 May;54(5):635-54
pubmed: 25752971
Breast Cancer Res Treat. 2015 Apr;150(3):655-66
pubmed: 25809092
Cancer Res. 2015 Jun 1;75(11):2375-2386
pubmed: 25840984
Int J Behav Nutr Phys Act. 2015 Mar 27;12:42
pubmed: 25890168
Psychooncology. 2016 Feb;25(2):142-9
pubmed: 25920528
Am J Prev Med. 2015 Sep;49(3):414-8
pubmed: 26071863
Br J Surg. 2015 Aug;102(9):1064-70
pubmed: 26075654
JAMA Oncol. 2015 Aug;1(5):611-21
pubmed: 26182172
Cancer. 2015 Oct 15;121(20):3700-8
pubmed: 26193782
J Clin Oncol. 2015 Oct 1;33(28):3169-76
pubmed: 26282657
Breast Cancer Res. 2015 Aug 19;17:112
pubmed: 26286584
Fertil Steril. 2015 Dec;104(6):1544-51
pubmed: 26385402
J Natl Cancer Inst. 2015 Sep 30;107(12):djv275
pubmed: 26424778
Cancer Causes Control. 2016 Jan;27(1):115-24
pubmed: 26518195
Oncotarget. 2016 Jan 12;7(2):1262-75
pubmed: 26556856
Clin Cancer Res. 2016 May 1;22(9):2283-9
pubmed: 26712688
BMJ Open. 2016 Jan 14;6(1):e007997
pubmed: 26769776
Cancer Causes Control. 2016 Mar;27(3):359-66
pubmed: 26797453
Sci Rep. 2016 Feb 22;6:21782
pubmed: 26899873
World J Methodol. 2016 Mar 26;6(1):43-55
pubmed: 27019796
BMC Med. 2016 Apr 05;14:62
pubmed: 27044418
Lancet. 2016 Apr 2;387(10026):1377-1396
pubmed: 27115820
Breast Cancer Res Treat. 2016 Jul;158(1):113-126
pubmed: 27283835
Bull Cancer. 2016 Jul-Aug;103(7-8):674-90
pubmed: 27286758
Lancet. 2016 Aug 20;388(10046):776-86
pubmed: 27423262
Ann Oncol. 2016 Nov;27(11):2053-2059
pubmed: 27502721
Curr Opin Pharmacol. 2016 Dec;31:1-7
pubmed: 27552697
N Engl J Med. 2016 Aug 25;375(8):794-8
pubmed: 27557308
Eur J Cancer. 2016 Oct;66:153-61
pubmed: 27573429
Nat Commun. 2016 Oct 06;7:13007
pubmed: 27708283
J Breast Cancer. 2016 Sep;19(3):283-291
pubmed: 27721878
Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):355-365
pubmed: 27742668
Sci Rep. 2016 Oct 27;6:36107
pubmed: 27786298
Cancer Prev Res (Phila). 2016 Nov;9(11):835-843
pubmed: 27803047
Curr Opin Pharmacol. 2016 Dec;31:83-89
pubmed: 27816025
Front Public Health. 2017 Jan 11;4:289
pubmed: 28123997
Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):444-457
pubmed: 28223433
J Oncol Pract. 2017 Feb;13(2):82-89
pubmed: 28387544
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Am J Epidemiol. 2017 Dec 15;186(12):1329-1340
pubmed: 28637226
Contemp Clin Trials. 2017 Oct;61:63-72
pubmed: 28739540
Oncotarget. 2017 May 13;8(43):75389-75399
pubmed: 29088874
NPJ Precis Oncol. 2017;1:null
pubmed: 29152592
BMC Cancer. 2017 Nov 22;17(1):785
pubmed: 29166878
Prog Lipid Res. 2018 Jan;69:11-20
pubmed: 29175445
BMC Public Health. 2017 Dec 08;17(1):936
pubmed: 29216920
J Acad Nutr Diet. 2018 Apr;118(4):578-588.e1
pubmed: 29233615
Cancer Treat Rev. 2018 Feb;63:79-95
pubmed: 29253837
FASEB J. 2018 Aug;32(8):4343-4355
pubmed: 29513571
Curr Oncol Rep. 2018 Apr 11;20(6):47
pubmed: 29644507
Eur J Obstet Gynecol Reprod Biol. 2018 Nov;230:217-221
pubmed: 29730021
BMC Cancer. 2018 May 31;18(1):616
pubmed: 29855282
J Acad Nutr Diet. 2018 Oct;118(10):1855-1863.e6
pubmed: 29859758
Mayo Clin Proc. 2018 Jun;93(6):794-807
pubmed: 29866283
Cell Metab. 2018 Jun 5;27(6):1357
pubmed: 29874570
Medicine (Baltimore). 2018 Jul;97(27):e11345
pubmed: 29979411
Oncology (Williston Park). 2018 Aug 15;32(8):410-7
pubmed: 30153321
J Clin Invest. 1995 May;95(5):2409-15
pubmed: 7738205
J Clin Oncol. 1996 Nov;14(11):3000-8
pubmed: 8918498
J Clin Oncol. 1998 Dec;16(12):3731-5
pubmed: 9850015