CTLA-4 Genetic Variants Predict Survival in Patients with Sepsis.
CTLA-4
haplotypes
predictors
sepsis
single nucleotide polymorphisms
survival
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
10 Jan 2019
10 Jan 2019
Historique:
received:
13
12
2018
revised:
26
12
2018
accepted:
07
01
2019
entrez:
13
1
2019
pubmed:
13
1
2019
medline:
13
1
2019
Statut:
epublish
Résumé
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is a coinhibitory checkpoint protein expressed on the surface of T cells. A recent study by our working group revealed that the rs231775 single nucleotide polymorphism (SNP) in the CTLA-4 gene was associated with the survival of patients with sepsis and served as an independent prognostic variable. To further investigate the impact of CTLA-4 genetic variants on sepsis survival, we examined the effect of two functional SNPs, CTLA-4 rs733618 and CTLA-4 rs3087243, and inferred haplotypes, on the survival of 644 prospectively enrolled septic patients. Kaplan⁻Meier survival analysis revealed significantly lower 90-day mortality for rs3087243 G allele carriers (
Identifiants
pubmed: 30634576
pii: jcm8010070
doi: 10.3390/jcm8010070
pmc: PMC6352177
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Volkswagen Foundation
ID : ZN3168
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