T Cells and Regulated Cell Death: Kill or Be Killed.
Apoptosis
Cancer immunotherapy
Cell death
Ferroptosis
Granzymes
Immunosurveillance
Necroptosis
Pyroptosis
T cell
Journal
International review of cell and molecular biology
ISSN: 1937-6448
Titre abrégé: Int Rev Cell Mol Biol
Pays: Netherlands
ID NLM: 101475846
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
13
1
2019
pubmed:
13
1
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
Cell death plays two major complementary roles in T cell biology: mediating the removal of cells that are targeted by T cells and the removal of T cells themselves. T cells serve as major actors in the adaptive immune response and function by selectively killing cells which are infected or dysfunctional. This feature is highly involved during homeostatic maintenance, and is relied upon and modulated in the context of cancer immunotherapy. The vital recognition and elimination of both autoreactive T cells and cells which are unable to recognize threats is a highly selective and regulated process. Moreover, detection of potential threats will result in the activation and expansion of T cells, which on resolution of the immune response will need to be eliminated. The culling of these T cells can be executed via a multitude of cell death pathways which are used in context-specific manners. Failure of these processes may result in an accumulation of misdirected or dysfunctional T cells, leading to complications such as autoimmunity or cancer. This review will focus on the role of cell death regulation in the maintenance of T cell homeostasis, as well as T cell-mediated elimination of infected or dysfunctional cells, and will summarize and discuss the current knowledge of the cellular mechanisms which are implicated in these processes.
Identifiants
pubmed: 30635093
pii: S1937-6448(18)30082-0
doi: 10.1016/bs.ircmb.2018.07.004
pmc: PMC7325157
mid: NIHMS1597638
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-71Subventions
Organisme : NCI NIH HHS
ID : K99 CA188679
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA188679
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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