Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants.

Adult Animals Animals, Newborn Antigens, Dermatophagoides Cell Differentiation Dendritic Cells / physiology Humans Hypersensitivity / immunology Immunization Infant Inflammation / immunology Lipopolysaccharides / immunology Mice Mice, Inbred C57BL Mice, Knockout Pyroglyphidae / immunology T-Box Domain Proteins / metabolism Th2 Cells / immunology Tumor Necrosis Factor-alpha / metabolism
CD11b(+) lung dendritic cells T-bet(+) dendritic cells TNF-α-driven activation Th2-driven inflammation house-dust mite neonatal and infant allergic responses

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
15 01 2019
Historique:
received: 08 08 2017
revised: 16 08 2018
accepted: 05 11 2018
pubmed: 13 1 2019
medline: 6 7 2019
entrez: 13 1 2019
Statut: ppublish

Résumé

Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that sensitization of mice with house-dust mites (HDMs) in the presence of low-dose lipopolysaccharide (LPS) prevented T helper 2 (Th2) cell allergic responses in adult, but not infant, mice. Mechanistically, adult CD11b

Identifiants

DOI: 10.1016/j.immuni.2018.11.012 PMID: 30635238 PMC: PMC6335154
pubmed: 30635238
pii: S1074-7613(18)30494-1
doi: 10.1016/j.immuni.2018.11.012
pmc: PMC6335154
mid: NIHMS1512591
pii:
doi:

Substances chimiques

Antigens, Dermatophagoides 0
Lipopolysaccharides 0
T-Box Domain Proteins 0
T-box transcription factor TBX21 0
Tumor Necrosis Factor-alpha 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

225-240.e4

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI110480
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116584
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR069516
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES026458
Pays : United States

Informations de copyright

Published by Elsevier Inc.

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Auteurs

Holly Bachus (H)

Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.

Kamaljeet Kaur (K)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Amber M Papillion (AM)

Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.

Tatiana T Marquez-Lago (TT)

Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.

Zhihong Yu (Z)

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.

André Ballesteros-Tato (A)

Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.

Sadis Matalon (S)

Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Beatriz León (B)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: bleon@uab.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de Dermatophagoides › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Arachnida › Acari › Mites (acariens) › Pyroglyphidae › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines à domaine boîte-T › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › Impaired Tumor-Necrosis-Factor-α-driven...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Impaired Tumor-Necrosis-Factor-α-driven...