Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.

2',5'-Oligoadenylate Synthetase / genetics Animals Cyclic AMP / metabolism DNA Virus Infections / immunology DNA Viruses / physiology Humans Interferon Type I / genetics Membrane Proteins / metabolism Mice Mice, Inbred C57BL Mice, Knockout Nucleotidyltransferases / metabolism RNA Virus Infections / immunology RNA Viruses / immunology RNA, Small Interfering / genetics Signal Transduction THP-1 Cells Virus Replication
DNA virus IFN OASL cGAMP cGAS transcriptional signalling

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
15 01 2019
Historique:
received: 05 06 2018
revised: 23 10 2018
accepted: 11 12 2018
pubmed: 13 1 2019
medline: 6 7 2019
entrez: 13 1 2019
Statut: ppublish

Résumé

Interferon-inducible human oligoadenylate synthetase-like (OASL) and its mouse ortholog, Oasl2, enhance RNA-sensor RIG-I-mediated type I interferon (IFN) induction and inhibit RNA virus replication. Here, we show that OASL and Oasl2 have the opposite effect in the context of DNA virus infection. In Oasl2

Identifiants

DOI: 10.1016/j.immuni.2018.12.013 PMID: 30635239 PMC: PMC6342484
pubmed: 30635239
pii: S1074-7613(18)30561-2
doi: 10.1016/j.immuni.2018.12.013
pmc: PMC6342484
mid: NIHMS1517018
pii:
doi:

Substances chimiques

Interferon Type I 0
Membrane Proteins 0
RNA, Small Interfering 0
Sting1 protein, mouse 0
Cyclic AMP E0399OZS9N
Nucleotidyltransferases EC 2.7.7.-
Oasl2 protein, mouse EC 2.7.7.-
cGAS protein, mouse EC 2.7.7.-
2',5'-Oligoadenylate Synthetase EC 2.7.7.84

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

51-63.e5

Subventions

Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118896
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178766
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211241
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Arundhati Ghosh (A)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Lulu Shao (L)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Padmavathi Sampath (P)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Baoyu Zhao (B)

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

Nidhi V Patel (NV)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Jianzhong Zhu (J)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Bharat Behl (B)

Department of Immunology, University of Connecticut Health School of Medicine, Farmington, CT 06030, USA.

Robert A Parise (RA)

Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA.

Jan H Beumer (JH)

Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA.

Roderick J O'Sullivan (RJ)

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Neal A DeLuca (NA)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Stephen H Thorne (SH)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Vijay A K Rathinam (VAK)

Department of Immunology, University of Connecticut Health School of Medicine, Farmington, CT 06030, USA.

Pingwei Li (P)

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

Saumendra N Sarkar (SN)

Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: saumen@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › 2',5'-Oligoadenylate synthetase › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Eucaryotes › Animaux › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ADN › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Virus › Virus à ADN › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Virus › Virus à ARN › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › Oligoadenylate-Synthetase-Family Protein OASL...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Oligoadenylate-Synthetase-Family Protein OASL...