Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation.

hypoxia-reoxygenation ischemic cardiomyopathy mitochondrial oxidants oxidative injury voltage-independent Ca2+ channels

Journal

Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222

Informations de publication

Date de publication:
Sep 2019
Historique:
received: 11 09 2018
accepted: 03 01 2019
pubmed: 15 1 2019
medline: 15 1 2019
entrez: 15 1 2019
Statut: ppublish

Résumé

The mechanisms by which Trpm2 channels enhance mitochondrial bioenergetics and protect against oxidative stress-induced cardiac injury remain unclear. Here, the role of proline-rich tyrosine kinase 2 (Pyk2) in Trpm2 signaling is explored. Activation of Trpm2 in adult myocytes with H

Identifiants

pubmed: 30637731
doi: 10.1002/jcp.28146
pmc: PMC6626587
mid: NIHMS1004801
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15048-15060

Subventions

Organisme : National Institute of Neurological Disorders and Stroke
ID : R21-NS098991
Organisme : National Heart, Lung, and Blood Institute
ID : PO1-HL91799
Organisme : NINDS NIH HHS
ID : U01 NS097162
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137266
Pays : United States
Organisme : National Heart, Lung, and Blood Institute
ID : RO1-HL093671
Organisme : National Institute of General Medical Sciences
ID : R01-GM117014
Organisme : National Heart, Lung, and Blood Institute
ID : RO1-HL122124
Organisme : NHLBI NIH HHS
ID : R01 HL119306
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK046778
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM109882
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137426
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS098991
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117014
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122124
Pays : United States
Organisme : National Heart, Lung, and Blood Institute
ID : RO1-HL86699
Organisme : National Heart, Lung, and Blood Institute
ID : RO1-HL137266
Organisme : NHLBI NIH HHS
ID : R01 HL093671
Pays : United States
Organisme : National Institute of Diabetes and Digestive and Kidney Diseases
ID : RO1-DK46778
Organisme : National Heart, Lung, and Blood Institute
ID : RO1-HL137426
Organisme : NHLBI NIH HHS
ID : P01 HL091799
Pays : United States
Organisme : National Heart, Lung, and Blood Institute
ID : RO1-HL123093
Organisme : National Institute of Neurological Disorders and Stroke
ID : UO1-NS097162
Organisme : NHLBI NIH HHS
ID : R01 HL086699
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123093
Pays : United States

Informations de copyright

© 2019 Wiley Periodicals, Inc.

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Auteurs

Barbara A Miller (BA)

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

JuFang Wang (J)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Jianliang Song (J)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Xue-Qian Zhang (XQ)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Iwona Hirschler-Laszkiewicz (I)

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Santhanam Shanmughapriya (S)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Department of Biochemistry, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Dhanendra Tomar (D)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Department of Biochemistry, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Sudasan Rajan (S)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Department of Biochemistry, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Arthur M Feldman (AM)

Department of Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Muniswamy Madesh (M)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Department of Biochemistry, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Shey-Shing Sheu (SS)

Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

Joseph Y Cheung (JY)

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.
Department of Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania.

Classifications MeSH