Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival.
GvHD
cellular therapies
clinical research
mesenchymal cells
stromal cells
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
03
10
2018
accepted:
11
12
2018
pubmed:
15
1
2019
medline:
20
2
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival. In our cohort, cell dose, patients' age and type of organ involvement are crucial factors associated with clinical responses.
Identifiants
pubmed: 30637732
doi: 10.1111/bjh.15749
pmc: PMC6916615
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-92Subventions
Organisme : Medical Research Council
ID : MC_G0802523
Pays : United Kingdom
Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
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