A case report of the long treatment experience of a Sézary syndrome responder patient: 16 years through all the systemic and innovative therapies.

Adult Antibodies, Monoclonal, Humanized / administration & dosage Deoxycytidine / administration & dosage Humans Male Sezary Syndrome / drug therapy Time Factors Gemcitabine
Sézary syndrome experimental drugs prolonged disease control

Journal

Hematological oncology
ISSN: 1099-1069
Titre abrégé: Hematol Oncol
Pays: England
ID NLM: 8307268

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 14 09 2018
revised: 08 01 2019
accepted: 09 01 2019
pubmed: 15 1 2019
medline: 8 5 2019
entrez: 15 1 2019
Statut: ppublish

Résumé

Existing therapies for Sézary syndrome (SS) are limited in efficacy and in disease control, and patients have very poor prognosis. Here, we report a case report of a patient who has a 16-year history of SS and related treatments (both standard and experimental). In particular, two drugs, one conventional (gemcitabine) and one experimental (mogamulizumab), were able to induce long lasting response. Patient refused to undergo allogeneic stem cell transplantation. After eleven lines of therapeutic approaches, the patient is in very good partial response and free of therapy at the latest available follow-up.

Identifiants

DOI: 10.1002/hon.2573 PMID: 30637815
pubmed: 30637815
doi: 10.1002/hon.2573
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
Deoxycytidine 0W860991D6
mogamulizumab YI437801BE
Gemcitabine 0

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

202-204

Informations de copyright

© 2019 John Wiley & Sons, Ltd.

Auteurs

Laura Nanni (L)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.

Alice Morigi (A)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.

Beatrice Casadei (B)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.

Alessandro Broccoli (A)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.
ORCID: 0000-0001-5633-7313

Vittorio Stefoni (V)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.

Lisa Argnani (L)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.

Michele Cavo (M)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.

Pier Luigi Zinzani (PL)

Institute of Hematology "L. e A. Seràgnoli,", University of Bologna, Bologna, Italy.
ORCID: 0000-0002-2112-2651

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A case report of the long treatment experience...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › A case report of the long treatment experience...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Désoxycytidine › A case report of the long treatment experience...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A case report of the long treatment experience...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Syndrome de Sézary › A case report of the long treatment experience...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › A case report of the long treatment experience...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Gemcitabine › A case report of the long treatment experience...