Ménage à trois: Virus, Host, and Microbiota in Experimental Infection Models.
commensal bacteria
innate immune response
microbiota
virus
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
03
09
2018
revised:
29
11
2018
accepted:
13
12
2018
pubmed:
15
1
2019
medline:
1
7
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Infections of mammals with pathogenic viruses occur mostly in the polymicrobial environment of mucosal surfaces or the skin. In recent years our understanding of immune modulation by the commensal microbiota has increased dramatically. The microbiota is today accepted as the prime educator and maintainer of innate and adaptive immune functions. It became further apparent that some viral pathogens profit from the presence of commensal bacteria and their metabolites, especially in the intestinal tract. We further learned that the composition and abundance of the microbiota can change as a consequence of acute and chronic viral infections. Here we discuss recent developments in our understanding of the triangular relationship of virus, host, and microbiota under experimental infection settings.
Identifiants
pubmed: 30638775
pii: S0966-842X(18)30280-4
doi: 10.1016/j.tim.2018.12.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
440-452Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.