In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ

Amyloid beta-Peptides / antagonists & inhibitors Animals Cell Survival / drug effects Dose-Response Relationship, Drug Neuroprotective Agents / pharmacology PC12 Cells Peptide Fragments / antagonists & inhibitors Protein Aggregates / drug effects Rats Xanthophylls / pharmacology
Alzheimer's disease Amyloid beta Astaxanthin Fucoxanthin Neuroprotection

Journal

Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959

Informations de publication

Date de publication:
03 2019
Historique:
received: 06 06 2018
revised: 31 12 2018
accepted: 08 01 2019
pubmed: 15 1 2019
medline: 25 12 2019
entrez: 15 1 2019
Statut: ppublish

Résumé

Amyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ

Identifiants

DOI: 10.1016/j.neuint.2019.01.010 PMID: 30639263
pubmed: 30639263
pii: S0197-0186(18)30249-3
doi: 10.1016/j.neuint.2019.01.010
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Neuroprotective Agents 0
Peptide Fragments 0
Protein Aggregates 0
Xanthophylls 0
amyloid beta-protein (1-42) 0
fucoxanthin 06O0TC0VSM
astaxanthine 8XPW32PR7I

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

215-224

Informations de copyright

Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.

Auteurs

Mousa Alghazwi (M)

Centre for Marine Bioproducts Development (CMBD), College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia; Medical Biotechnology, College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia; Ministry of Higher Education in Saudi Arabia, King Faisal Hospital Street, Riyadh, 11153, Saudi Arabia. Electronic address: algh0068@flinders.edu.au.

Scott Smid (S)

Discipline of Pharmacology, School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address: scott.smid@adelaide.edu.au.

Ian Musgrave (I)

Discipline of Pharmacology, School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address: ian.musgrave@adelaide.edu.au.

Wei Zhang (W)

Centre for Marine Bioproducts Development (CMBD), College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia; Medical Biotechnology, College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia. Electronic address: Wei.zhang@flinders.edu.au.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › In vitro studies of the neuroprotective...
questionsmedicales.fr › Eucaryotes › Animaux › In vitro studies of the neuroprotective...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › In vitro studies of the neuroprotective...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › In vitro studies of the neuroprotective...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › In vitro studies of the neuroprotective...
questionsmedicales.fr › Cellules › Cellules chromaffines › Cellules PC12 › In vitro studies of the neuroprotective...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › In vitro studies of the neuroprotective...
questionsmedicales.fr › Structures macromoléculaires › Agrégats de protéines › In vitro studies of the neuroprotective...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › In vitro studies of the neuroprotective...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Xanthophylles › In vitro studies of the neuroprotective...