Prospective association of white matter hyperintensity volume and frailty in older adults.
Frailty
Imaging
Small vessel disease
White matter
Journal
Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
24
07
2018
revised:
04
01
2019
accepted:
08
01
2019
pubmed:
15
1
2019
medline:
19
6
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Frailty is a prevalent geriatric condition and its association with brain health is still weakly investigated. The objective of this study was to examine whether brain white matter hyperintensities (WMH) were related to longitudinal changes in frailty severity in community-dwelling older adults. 113 community-dwelling older adults, aged 70 years and over, enrolled in the placebo group from the 3-year Multidomain Alzheimer's Preventive Trial (MAPT). Frailty was assessed using Fried's frailty phenotype as an ordinal variable (range from 0 to 5, higher is worse) at baseline, 6, 12, 24 and 36 months. We obtained brain WMH data using magnetic resonance imaging (MRI) at the first and last year of the trial. The progression of WMH volume was evaluated. We included 113 baseline and 83 follow-up MRIs in this study. The median baseline WMH volume was 10.6 (6.0, 15.0) cm WMH were associated with frailty severity over time. Why the progression of WMH was not associated with changes in frailty severity requires further investigation.
Sections du résumé
BACKGROUND
Frailty is a prevalent geriatric condition and its association with brain health is still weakly investigated. The objective of this study was to examine whether brain white matter hyperintensities (WMH) were related to longitudinal changes in frailty severity in community-dwelling older adults.
METHODS
113 community-dwelling older adults, aged 70 years and over, enrolled in the placebo group from the 3-year Multidomain Alzheimer's Preventive Trial (MAPT). Frailty was assessed using Fried's frailty phenotype as an ordinal variable (range from 0 to 5, higher is worse) at baseline, 6, 12, 24 and 36 months. We obtained brain WMH data using magnetic resonance imaging (MRI) at the first and last year of the trial. The progression of WMH volume was evaluated.
RESULTS
We included 113 baseline and 83 follow-up MRIs in this study. The median baseline WMH volume was 10.6 (6.0, 15.0) cm
CONCLUSION
WMH were associated with frailty severity over time. Why the progression of WMH was not associated with changes in frailty severity requires further investigation.
Identifiants
pubmed: 30639444
pii: S0531-5565(18)30491-1
doi: 10.1016/j.exger.2019.01.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-54Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.