Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells.
Adolescent
Adult
Aged
Blood Circulation
Cell Separation
Female
Flow Cytometry
Gene Expression Regulation
Healthy Volunteers
Humans
Immunity, Cellular
Male
Middle Aged
Receptors, Tumor Necrosis Factor, Type I
/ genetics
Receptors, Tumor Necrosis Factor, Type II
/ metabolism
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Transcriptome
Tumor Necrosis Factor-alpha
/ metabolism
Young Adult
Cellular immunology
Cytokine receptors expression
Immune regulation
Journal
Immunology letters
ISSN: 1879-0542
Titre abrégé: Immunol Lett
Pays: Netherlands
ID NLM: 7910006
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
19
10
2018
revised:
12
12
2018
accepted:
09
01
2019
pubmed:
15
1
2019
medline:
18
2
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Flow cytometry analysis was used to study whole populations as well as subsets (T regulatory cells, T memory cells, cytotoxic T cells, T helper cells). Significant differences in the co-expression of TNFR1/2 were seen within subsets and total pools. Further studies are necessary to explore the implications of the observed differences in the modulation of tumor necrosis factor α function in health and pathology.
Identifiants
pubmed: 30639514
pii: S0165-2478(18)30464-4
doi: 10.1016/j.imlet.2019.01.005
pii:
doi:
Substances chimiques
Receptors, Tumor Necrosis Factor, Type I
0
Receptors, Tumor Necrosis Factor, Type II
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-5Informations de copyright
Copyright © 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.