Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis.
Anticancer therapy
Cancer
Ferroptosis
Necroptosis
ROS
Redox changes
Regulated cell death
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
11
2018
revised:
23
12
2018
accepted:
06
01
2019
pubmed:
15
1
2019
medline:
27
3
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Redox changes and generation of reactive oxygen species (ROS) are part of normal cell metabolism. While low ROS levels are implicated in cellular signaling pathways necessary for survival, higher levels play major roles in cancer development as well as cell death signaling and execution. A role for redox changes in apoptosis has been long established; however, several new modalities of regulated cell death have been brought to light, for which the importance of ROS production as well as ROS source and targets are being actively investigated. In this review, we summarize recent findings on the role of ROS and redox changes in the activation and execution of two major forms of regulated cell death, necroptosis and ferroptosis. We also discuss the potential of using modulators of these two forms of cell death to exacerbate ROS as a promising anticancer therapy.
Identifiants
pubmed: 30639617
pii: S0891-5849(18)32332-3
doi: 10.1016/j.freeradbiomed.2019.01.008
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-189Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.