Studies on batch formulation of a freeze dried kit for the preparation of
Aged
Animals
Cell Line, Tumor
Drug Compounding
/ methods
Freeze Drying
Humans
Male
Mice
Mice, Nude
Middle Aged
Neuroendocrine Tumors
/ diagnostic imaging
Octreotide
/ analogs & derivatives
Organotechnetium Compounds
/ isolation & purification
Radiopharmaceuticals
/ isolation & purification
Single Photon Emission Computed Tomography Computed Tomography
Whole Body Imaging
(99m)Tc-HYNIC-Octreotate ((99m)Tc-HYNIC-TATE)
Diagnostic imaging
Neuroendocrine tumors (NET)
Somatostatin receptors
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
25
06
2018
revised:
10
10
2018
accepted:
20
12
2018
pubmed:
15
1
2019
medline:
26
7
2019
entrez:
15
1
2019
Statut:
ppublish
Résumé
To formulate freeze dried cold kits for preparation of Standardization of reagent concentrations for formulation of freeze dried kits of HYNIC-TATE was carried out. Consistency in formulation was tested by six batch preparation. Quality control tests were carried out to establish compliance of specifications of purity and safety criteria for both kits and Pharmaceutical grade HYNIC-TATE kits compliant with all the quality control criteria were formulated and successfully radiolabeled with The formulated kits are robust and provide consistently high radiolabeling yields (> 95%) with
Identifiants
pubmed: 30639635
pii: S0969-8043(18)30589-X
doi: 10.1016/j.apradiso.2018.12.027
pii:
doi:
Substances chimiques
Organotechnetium Compounds
0
Radiopharmaceuticals
0
technetium Tc 99m hydrazinonicotinyl-Tyr(3)-Thr(8)-octreotide
0
Octreotide
RWM8CCW8GP
Types de publication
Evaluation Study
Journal Article
Langues
eng
Pagination
180-186Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.