In seroconverted rheumatoid arthritis patients a multi-reactive anti-herpes IgM profile is associated with disease activity.
Antibodies, Viral
/ immunology
Antirheumatic Agents
/ therapeutic use
Arthritis, Rheumatoid
/ drug therapy
Case-Control Studies
Cytomegalovirus
/ genetics
DNA, Viral
/ analysis
Family
Female
Herpesviridae
/ genetics
Herpesvirus 1, Human
/ genetics
Herpesvirus 2, Human
/ genetics
Herpesvirus 4, Human
/ genetics
Humans
Immunoglobulin G
/ immunology
Immunoglobulin M
/ immunology
Male
Middle Aged
Seroconversion
Severity of Illness Index
Virus Activation
/ immunology
CMV
Disease activity
EBV
HSV
Reactivation
Rheumatoid arthritis
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
26
10
2018
revised:
09
01
2019
accepted:
10
01
2019
pubmed:
15
1
2019
medline:
1
1
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Conflicting results have been reported regarding human herpes virus (HHV) reactivation in patients with rheumatoid arthritis (RA). To explore this link, 74 RA patients were selected and compared to 42 first degree relatives (FDR) from probands with RA and 25 healthy controls from the Tatarstan women cohort. The serological analysis was done by testing anti-HSV/CMV/EBV IgM, IgG, plus the IgG avidity index, and completed by evaluating HSV/CMV/EBV DNA by PCR. Results from these analyses reveal: (i) a long lasting infection of HHV in RA, FDR and healthy controls (IgG seroconversion >97%); (ii) an elevated IgM anti-HHV response in seroconverted RA patients which is related to HSV1/2 reactivation (HSV1/2 PCR+); and (iii) a multi-reactive IgM HHV burden profile associated with disease activity (DAS28). In conclusion, HSV1/2 reactivation in seroconverted RA patients is associated with an abnormal anti-HHV immune response, which was reflected in IgM HHV burden, and in activity disease profile.
Identifiants
pubmed: 30639657
pii: S1521-6616(18)30629-6
doi: 10.1016/j.clim.2019.01.004
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Antirheumatic Agents
0
DNA, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-23Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.