Comparison of Outcomes of Allogeneic Hematopoietic Cell Transplantation for Multiple Myeloma Using Three Different Conditioning Regimens.
Adult
Aged
Busulfan
/ therapeutic use
Butyrophenones
/ therapeutic use
Clinical Trials as Topic
Female
Graft vs Host Disease
/ etiology
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Male
Middle Aged
Multiple Myeloma
/ mortality
Prognosis
Retrospective Studies
Survival Analysis
Transplantation Conditioning
/ methods
Transplantation, Homologous
Treatment Outcome
Vidarabine
/ analogs & derivatives
Allogeneic hematopoietic cell transplant
Conditioning regimens
Multiple myeloma
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
30
08
2018
accepted:
07
01
2019
pubmed:
15
1
2019
medline:
21
3
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for patients with multiple myeloma, as it provides a graft-versus-myeloma effect alongside a myeloma-free graft. Although reduced-intensity conditioning regimens decrease nonrelapse mortality (NRM), there is a paucity of data with regard to the ideal conditioning regimen in myeloma. We conducted a retrospective comparison of 3 different preparative regimens used for allo-HCT for multiple myeloma at our institution in recent clinical trials: busulfan/fludarabine (BuFlu), fludarabine/melphalan 100 mg/m
Identifiants
pubmed: 30639822
pii: S1083-8791(19)30024-2
doi: 10.1016/j.bbmt.2019.01.009
pmc: PMC7053532
mid: NIHMS1066114
pii:
doi:
Substances chimiques
Butyrophenones
0
Vidarabine
FA2DM6879K
Busulfan
G1LN9045DK
metylperon
J8WA3K39B7
fludarabine
P2K93U8740
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1039-1044Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009666
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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