Maximum Entropy Based Non-Negative Optoacoustic Tomographic Image Reconstruction.


Journal

IEEE transactions on bio-medical engineering
ISSN: 1558-2531
Titre abrégé: IEEE Trans Biomed Eng
Pays: United States
ID NLM: 0012737

Informations de publication

Date de publication:
09 2019
Historique:
pubmed: 15 1 2019
medline: 28 4 2020
entrez: 15 1 2019
Statut: ppublish

Résumé

Optoacoustic (photoacoustic) tomography is aimed at reconstructing maps of the initial pressure rise induced by the absorption of light pulses in tissue. In practice, due to inaccurate assumptions in the forward model, noise, and other experimental factors, the images are often afflicted by artifacts, occasionally manifested as negative values. The aim of this work is to develop an inversion method which reduces the occurrence of negative values and improves the quantitative performance of optoacoustic imaging. We present a novel method for optoacoustic tomography based on an entropy maximization algorithm, which uses logarithmic regularization for attaining non-negative reconstructions. The reconstruction image quality is further improved using structural prior-based fluence correction. We report the performance achieved by the entropy maximization scheme on numerical simulation, experimental phantoms, and in-vivo samples. The proposed algorithm demonstrates superior reconstruction performance by delivering non-negative pixel values with no visible distortion of anatomical structures. Our method can enable quantitative optoacoustic imaging, and has the potential to improve preclinical and translational imaging applications.

Identifiants

pubmed: 30640596
doi: 10.1109/TBME.2019.2892842
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2604-2616

Subventions

Organisme : NEI NIH HHS
ID : R21 EY026382
Pays : United States

Auteurs

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Classifications MeSH