Single chain peptide agonists of relaxin receptors.

Amino Acid Sequence Animals Humans Peptides / chemistry Receptors, G-Protein-Coupled / agonists Receptors, Peptide / agonists Relaxin / chemistry Structure-Activity Relationship
Insulin-like peptide Relaxin Relaxin-2 Relaxin-3

Journal

Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844

Informations de publication

Date de publication:
01 05 2019
Historique:
received: 01 11 2018
revised: 08 01 2019
accepted: 10 01 2019
pubmed: 15 1 2019
medline: 16 1 2020
entrez: 15 1 2019
Statut: ppublish

Résumé

There are seven human relaxin family peptides that have two chains (A and B) and three disulfide bonds. The target receptors for four of these peptides are known as relaxin family peptide receptors, RXFP1-RXFP4. Detailed structure-activity relationship (SAR) studies of relaxin family peptides have been reported over the years and have led to the design of new analogs with agonistic and antagonistic properties. This review briefly summarizes the SAR of human relaxin 2 (H2 relaxin) and human relaxin 3 (H3 relaxin) leading to the design and development of single-B-chain only agonists, B7-33 and peptide 5. The physiological functions of these new peptides agonists in cellular and animal models are also described.

Identifiants

DOI: 10.1016/j.mce.2019.01.008 PMID: 30641102
pubmed: 30641102
pii: S0303-7207(19)30008-5
doi: 10.1016/j.mce.2019.01.008
pii:
doi:

Substances chimiques

Peptides 0
Receptors, G-Protein-Coupled 0
Receptors, Peptide 0
relaxin receptors 0
Relaxin 9002-69-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-39

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Praveen Praveen (P)

Florey Institute for Neuroscience & Mental Health, VIC, Australia.

Martina Kocan (M)

Florey Institute for Neuroscience & Mental Health, VIC, Australia.

Adam Valkovic (A)

Florey Institute for Neuroscience & Mental Health, VIC, Australia.

Ross Bathgate (R)

Florey Institute for Neuroscience & Mental Health, VIC, Australia; Department of Biochemistry and Molecular Biology, University of Melbourne, VIC, Australia.

Mohammed Akhter Hossain (MA)

Florey Institute for Neuroscience & Mental Health, VIC, Australia; School of Chemistry and Bio21, University of Melbourne, University of Melbourne, VIC, Australia. Electronic address: akhter.hossain@unimelb.edu.au.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Eucaryotes › Animaux › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Relaxine › Single chain peptide agonists of relaxin receptors.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Single chain peptide agonists of relaxin receptors.