Lung cancer risk assessment for workers exposed to polycyclic aromatic hydrocarbons in various industries.
Human lung cancer risk assessment
Inhalation exposure
Modeling
PAHs
Risk probability
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
04
10
2018
revised:
14
12
2018
accepted:
28
12
2018
pubmed:
15
1
2019
medline:
11
7
2019
entrez:
15
1
2019
Statut:
ppublish
Résumé
Millions of workers are exposed to carcinogenic polycyclic aromatic hydrocarbon (PAH) mixtures. The toxicity of PAH mixtures is variable and depends on the composition of the mixture, which is related to the emission sources. Although several indicators exist, the cancer risk estimation associated with occupational exposure to PAHs is poorly known. To assess the risk of lung cancer associated with PAHs in several industries using the atmospheric concentrations of benzo[a]pyrene (BaP) as a proxy. A total of 93 exposure groups belonging to 9 industries were investigated. Eight indicators found in the literature were compared to assess risks. A consensual indicator was used to estimate lung cancer risks. Approximately 30% of the exposure groups were above the maximal risk level of the European Union (10 This study provides an overview of cancer risk estimation in many industries. Despite efforts and changes that had been made to decrease risks, PAHs remain a sanitary threat for people exposed to these pollutants in occupational environments.
Sections du résumé
BACKGROUND
Millions of workers are exposed to carcinogenic polycyclic aromatic hydrocarbon (PAH) mixtures. The toxicity of PAH mixtures is variable and depends on the composition of the mixture, which is related to the emission sources. Although several indicators exist, the cancer risk estimation associated with occupational exposure to PAHs is poorly known.
OBJECTIVES
To assess the risk of lung cancer associated with PAHs in several industries using the atmospheric concentrations of benzo[a]pyrene (BaP) as a proxy.
METHODS
A total of 93 exposure groups belonging to 9 industries were investigated. Eight indicators found in the literature were compared to assess risks. A consensual indicator was used to estimate lung cancer risks.
RESULTS
Approximately 30% of the exposure groups were above the maximal risk level of the European Union (10
CONCLUSION
This study provides an overview of cancer risk estimation in many industries. Despite efforts and changes that had been made to decrease risks, PAHs remain a sanitary threat for people exposed to these pollutants in occupational environments.
Identifiants
pubmed: 30641254
pii: S0160-4120(18)32270-0
doi: 10.1016/j.envint.2018.12.058
pii:
doi:
Substances chimiques
Coke
0
Environmental Pollutants
0
Polycyclic Aromatic Hydrocarbons
0
Vehicle Emissions
0
Benzo(a)pyrene
3417WMA06D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-120Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.