Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
Clostridium botulinum
SNARE proteins
botulinum neurotoxins
botulism
neuroexocytosis
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
11 01 2019
11 01 2019
Historique:
received:
14
11
2018
revised:
03
01
2019
accepted:
09
01
2019
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant and chemical poisonous compounds. Although a great effort has been made to understand their mode of action, some questions are still open. Why, and for what benefit, have environmental bacteria that accidentally interact with their host engineered so diverse and so specific toxins targeting one of the most specialized physiological processes, the neuroexocytosis of higher organisms? The extreme potency of BoNT does not result from only one hyperactive step, but in contrast to other potent lethal toxins, from multi-step activity. The cumulative effects of the different steps, each having a limited effect, make BoNTs the most potent lethal toxins. This is a unique mode of evolution of a toxic compound, the high potency of which results from multiple steps driven by unknown selection pressure, targeting one of the most critical physiological process of higher organisms.
Identifiants
pubmed: 30641949
pii: toxins11010034
doi: 10.3390/toxins11010034
pmc: PMC6357194
pii:
doi:
Substances chimiques
Neurotoxins
0
Botulinum Toxins
EC 3.4.24.69
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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