Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables.
DNA methylation
adipose tissue
epigenetics
metabolic syndrome
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
13 Jan 2019
13 Jan 2019
Historique:
received:
04
12
2018
revised:
09
01
2019
accepted:
10
01
2019
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
16
1
2019
Statut:
epublish
Résumé
Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic homeostasis, and AT dysfunction has an active role in metabolic diseases. MetS is closely related to lifestyle and environmental factors. Epigenetics has emerged as an interesting landscape to evaluate the possible interconnection between AT and metabolic disease, since it can be modulated by environmental factors and metabolic status. The aim of this study was to determine whether MetS has an impact on the global DNA methylation pattern and the DNA methylation of several genes related to adipogenesis (PPARG, PPARA), lipid metabolism (RXRA, SREBF2, SREBF1, SCD, LPL, LXRb), and inflammation (LRP1 C3, LEP and TNF) in visceral adipose tissue. LPL and TNF DNA methylation values were significantly different in the control-case comparisons, with higher and lower methylation respectively in the MetS group. Negative correlations were found between global DNA methylation (measured by LINE-1 methylation levels) and the metabolic deterioration and glucose levels. There were associations among variables of MetS, BMI, and HOMA-IR with DNA methylation at several CpG positions for the studied genes. In particular, there was a strong positive association between serum triglyceride levels (TG) with PPARA and LPL methylation levels. TNF methylation was negatively associated with the metabolic worsening and could be an important factor in preventing MetS occurrence according to logistic regression analysis. Therefore, global DNA methylation and methylation at specific genes related to adipogenesis, lipid metabolism and inflammation are related to the etiology of MetS and might explain in part some of the features associated to metabolic disorders.
Identifiants
pubmed: 30642114
pii: jcm8010087
doi: 10.3390/jcm8010087
pmc: PMC6352101
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : ISCIII-Co-Funded by Fondo Europeo de Desarrollo Regional-FEDER
ID : CP16/00163
Organisme : ISCIII-Co-Funded by Fondo Europeo de Desarrollo Regional-FEDER
ID : CPI13/00065
Organisme : Ministerio de Educación, Cultura y Deporte-Co-Funded by Fondo Europeo de Desarrollo Regional-FEDER
ID : FPU13/04211
Organisme : Consejería de Salud, co-funded by the Fondo Europeo de Desarrollo Regional - FEDER
ID : C-0032-2016
Organisme : Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional - FEDER
ID : PI08/1655; PI11/02518; PI14/00082
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