Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report.
Adrenal Cortex Hormones
/ therapeutic use
Aged
Anti-Bacterial Agents
/ therapeutic use
Disease Progression
Humans
Idiopathic Pulmonary Fibrosis
/ complications
Macrolides
/ therapeutic use
Male
Middle Aged
Respiratory Distress Syndrome
/ drug therapy
Tomography, X-Ray Computed
Whooping Cough
/ complications
Acute exacerbation
Idiopathic interstitial pneumonia
Idiopathic pulmonary fibrosis
Pertussis
Whooping cough
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
14 Jan 2019
14 Jan 2019
Historique:
received:
28
07
2018
accepted:
02
01
2019
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
7
5
2019
Statut:
epublish
Résumé
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertussis infection as a cause. Here we report two cases of pertussis infection-induced AE-IPF. Both patients presented with a chief complaint of acute respiratory distress and were previously diagnosed with idiopathic pulmonary fibrosis (IPF). Neither patient had received any pertussis vaccination since adolescence. Both patients were diagnosed with AE-IPF accompanying acute pertussis infection based on chest computed tomography and serum pertussis toxin antibody > 100 EU/mL. Both patients were treated with macrolide antibiotics and systemic corticosteroids. Both patients were able to be discharged and return home. The presence of pertussis infection in AE-IPF can present a diagnostic challenge, as coughing accompanying pertussis may be difficult to distinguish from IPF-associated coughing. Pertussis infection should be assayed in AE-IPF patients. Since pertussis can be prevented with vaccination and is expected to be affected by antibiotics, consideration of pertussis infection as a causative virulent factor of AE-IPF may be important for management of subjects with IPF.
Sections du résumé
BACKGROUND
BACKGROUND
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertussis infection as a cause. Here we report two cases of pertussis infection-induced AE-IPF.
CASE PRESENTATION
METHODS
Both patients presented with a chief complaint of acute respiratory distress and were previously diagnosed with idiopathic pulmonary fibrosis (IPF). Neither patient had received any pertussis vaccination since adolescence. Both patients were diagnosed with AE-IPF accompanying acute pertussis infection based on chest computed tomography and serum pertussis toxin antibody > 100 EU/mL. Both patients were treated with macrolide antibiotics and systemic corticosteroids. Both patients were able to be discharged and return home.
CONCLUSIONS
CONCLUSIONS
The presence of pertussis infection in AE-IPF can present a diagnostic challenge, as coughing accompanying pertussis may be difficult to distinguish from IPF-associated coughing. Pertussis infection should be assayed in AE-IPF patients. Since pertussis can be prevented with vaccination and is expected to be affected by antibiotics, consideration of pertussis infection as a causative virulent factor of AE-IPF may be important for management of subjects with IPF.
Identifiants
pubmed: 30642317
doi: 10.1186/s12890-019-0779-9
pii: 10.1186/s12890-019-0779-9
pmc: PMC6332631
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Anti-Bacterial Agents
0
Macrolides
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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