LUBAC determines chemotherapy resistance in squamous cell lung cancer.

Adenocarcinoma of Lung / drug therapy Animals Carcinoma, Squamous Cell / drug therapy Cisplatin / pharmacology Drug Resistance, Neoplasm Humans Lung Neoplasms / drug therapy Mice Multienzyme Complexes / genetics Proto-Oncogene Proteins p21(ras) / genetics Ubiquitination

Journal

The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R

Informations de publication

Date de publication:
04 02 2019
Historique:
received: 20 04 2018
revised: 20 11 2018
accepted: 18 12 2018
pubmed: 16 1 2019
medline: 18 12 2019
entrez: 16 1 2019
Statut: ppublish

Résumé

Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor suppressor FBW7 is commonly mutated or down-regulated in human LSCC, and oncogenic

Identifiants

DOI: 10.1084/jem.20180742 PMID: 30642944 PMC: PMC6363428
pubmed: 30642944
pii: jem.20180742
doi: 10.1084/jem.20180742
pmc: PMC6363428
doi:

Substances chimiques

KRAS protein, human 0
Multienzyme Complexes 0
Hras protein, mouse EC 3.6.5.2
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2
Cisplatin Q20Q21Q62J

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

450-465

Subventions

Organisme : Medical Research Council
ID : FC001039
Pays : United Kingdom
Organisme : Worldwide Cancer Research
ID : 12-0149
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001039
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001039
Pays : United Kingdom
Organisme : European Research Council
ID : 281661
Pays : International
Organisme : Medical Research Council
ID : MR/M019217/1
Pays : United Kingdom
Organisme : Worldwide Cancer Research
ID : 14-1328
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S000011/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

© 2019 Ruiz et al.

Références

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Auteurs

E Josue Ruiz (EJ)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.

Markus E Diefenbacher (ME)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.

Jessica K Nelson (JK)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.

Rocio Sancho (R)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-4894-5391

Fabio Pucci (F)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.

Atanu Chakraborty (A)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.

Paula Moreno (P)

Instituto Maimónides de Investigación Biomédica de Córdoba, Córdoba, Spain.
Unidad de Cirugía Torácica y Trasplante Pulmonar, Hospital Universitario Reina Sofía, Córdoba, Spain.

Alessandro Annibaldi (A)

Breast Cancer Now, Toby Robins Research Centre, Institute of Cancer Research, London, UK.

Gianmaria Liccardi (G)

Breast Cancer Now, Toby Robins Research Centre, Institute of Cancer Research, London, UK.

Vesela Encheva (V)

Proteomics, The Francis Crick Institute, London, UK.

Richard Mitter (R)

Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-1279-3760

Mathias Rosenfeldt (M)

Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.

Ambrosius P Snijders (AP)

Proteomics, The Francis Crick Institute, London, UK.

Pascal Meier (P)

Breast Cancer Now, Toby Robins Research Centre, Institute of Cancer Research, London, UK.

Marco A Calzado (MA)

Instituto Maimónides de Investigación Biomédica de Córdoba, Córdoba, Spain.
Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain.
ORCID: 0000-0002-5338-535X

Axel Behrens (A)

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK axel.behrens@crick.ac.uk.
Faculty of Life Sciences and Medicine, King's College London, London, UK.
ORCID: 0000-0002-1557-1143

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Eucaryotes › Animaux › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Cisplatine › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › LUBAC determines chemotherapy resistance in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › LUBAC determines chemotherapy resistance in...