TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
30
08
2018
accepted:
13
12
2018
pubmed:
16
1
2019
medline:
28
10
2019
entrez:
16
1
2019
Statut:
ppublish
Résumé
Characterizing self-tolerance mechanisms and their failure is critical to understand immune homeostasis, cancer immunity, and autoimmunity. However, examination of self-tolerance mechanisms has relied primarily on transgenic mice expressing TCRs targeting well-characterized, but nonphysiologic, model Ags, such as OVA and hemagglutinin. Identifying TCRs directed against bona fide self-antigens is made difficult by the extraordinary diversity of TCRs and the low prevalence of Ag-specific clones (<10-100 naive cells per organism), limiting dissection of tolerance mechanisms restricting immunity to self-proteins. In this study, we isolated and characterized TCRs recognizing the intestinal epithelial cell receptor and colorectal cancer Ag GUCY2C to establish a model to study self-antigen-specific tolerance mechanisms. GUCY2C-specific CD4
Identifiants
pubmed: 30642983
pii: jimmunol.1801206
doi: 10.4049/jimmunol.1801206
pmc: PMC6363846
mid: NIHMS1516865
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Gucy2c protein, mouse
EC 4.6.1.2
Receptors, Enterotoxin
EC 4.6.1.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1301-1310Subventions
Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204481
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206026
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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