Thymic regulatory T cells arise via two distinct developmental programs.

Animals Autoantigens / immunology Cell Differentiation / immunology Colitis / immunology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental / immunology Forkhead Transcription Factors / genetics Freund's Adjuvant / administration & dosage Humans Immune Tolerance / immunology Interleukin-2 Receptor alpha Subunit / metabolism Lymphoid Progenitor Cells / physiology Mice Mice, Transgenic Mycobacterium tuberculosis / immunology Myelin-Oligodendrocyte Glycoprotein / administration & dosage Peptide Fragments / administration & dosage Signal Transduction Specific Pathogen-Free Organisms T-Lymphocytes, Regulatory / physiology Thymus Gland / cytology

Journal

Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354

Informations de publication

Date de publication:
02 2019
Historique:
received: 07 03 2018
accepted: 21 11 2018
pubmed: 16 1 2019
medline: 7 5 2019
entrez: 16 1 2019
Statut: ppublish

Résumé

The developmental programs that generate a broad repertoire of regulatory T cells (T

Identifiants

DOI: 10.1038/s41590-018-0289-6 PMID: 30643267 PMC: PMC6650268
pubmed: 30643267
doi: 10.1038/s41590-018-0289-6
pii: 10.1038/s41590-018-0289-6
pmc: PMC6650268
mid: NIHMS1514192
doi:

Substances chimiques

Autoantigens 0
Forkhead Transcription Factors 0
Foxp3 protein, mouse 0
Il2ra protein, mouse 0
Interleukin-2 Receptor alpha Subunit 0
Myelin-Oligodendrocyte Glycoprotein 0
Peptide Fragments 0
myelin oligodendrocyte glycoprotein (35-55) 0
Freund's Adjuvant 9007-81-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

195-205

Subventions

Organisme : NIAID NIH HHS
ID : R56 AI113138
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK042086
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154998
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106791
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI126814
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK096844
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM110760
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI115716
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008568
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI097113
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI108958
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA185062
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK111914
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129422
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007313
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007334
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA151845
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA077598
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI035296
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI061165
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI061165
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085090
Pays : United States
Organisme : NIAID NIH HHS
ID : U24 AI118635
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120701
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI097457
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124512
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107027
Pays : United States

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Auteurs

David L Owen (DL)

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Shawn A Mahmud (SA)

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Louisa E Sjaastad (LE)

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Jason B Williams (JB)

Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Justin A Spanier (JA)

Center for Immunology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Dimitre R Simeonov (DR)

Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
ORCID: 0000-0002-1693-8664

Roland Ruscher (R)

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Weishan Huang (W)

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
ORCID: 0000-0002-1330-1131

Irina Proekt (I)

Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
ORCID: 0000-0003-3818-1102

Corey N Miller (CN)

Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
ORCID: 0000-0002-1291-0074

Can Hekim (C)

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Jonathan C Jeschke (JC)

Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Praful Aggarwal (P)

Section of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Ulrich Broeckel (U)

Section of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Rebecca S LaRue (RS)

Supercomputing Institute for Advanced Computational Research, University of Minnesota, Minneapolis, MN, USA.

Christine M Henzler (CM)

Supercomputing Institute for Advanced Computational Research, University of Minnesota, Minneapolis, MN, USA.

Maria-Luisa Alegre (ML)

Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.

Mark S Anderson (MS)

Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

Avery August (A)

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
ORCID: 0000-0003-4968-3415

Alexander Marson (A)

Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Chan Zuckerberg Biohub, San Francisco, San Francisco, CA, USA.
Innovative Genomics Institute, University of California, Berkeley, CA, USA.

Ye Zheng (Y)

Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA.
ORCID: 0000-0001-5012-4309

Calvin B Williams (CB)

Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Michael A Farrar (MA)

Center for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. farra005@umn.edu.
ORCID: 0000-0002-5569-0366

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Mélanges complexes › Adjuvant Freund › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-2 › Sous-unité alpha du récepteur à l'interleukine-2 › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Progéniteurs lymphoïdes › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Glycoprotéine MOG › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Phénomènes microbiologiques › Axénie › Organismes exempts d'organismes pathogènes spécifiques › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Thymic regulatory T cells arise via two...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Thymic regulatory T cells arise via two...