Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology.
cell engineering
mammalian cells
optogenetics
synthetic biology
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
09 Jan 2019
09 Jan 2019
Historique:
received:
20
06
2018
revised:
21
08
2018
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
16
1
2019
Statut:
epublish
Résumé
The ability to remote control the expression of therapeutic genes in mammalian cells in order to treat disease is a central goal of synthetic biology-inspired therapeutic strategies. Furthermore, optogenetics, a combination of light and genetic sciences, provides an unprecedented ability to use light for precise control of various cellular activities with high spatiotemporal resolution. Recent work to combine optogenetics and therapeutic synthetic biology has led to the engineering of light-controllable designer cells, whose behavior can be regulated precisely and noninvasively. This Review focuses mainly on non-neural optogenetic systems, which are often used in synthetic biology, and their applications in genetic programing of mammalian cells. Here, a brief overview of the optogenetic tool kit that is available to build light-sensitive mammalian cells is provided. Then, recently developed strategies for the control of designer cells with specific biological functions are summarized. Recent translational applications of optogenetically engineered cells are also highlighted, ranging from in vitro basic research to in vivo light-controlled gene therapy. Finally, current bottlenecks, possible solutions, and future prospects for optogenetics in synthetic biology are discussed.
Identifiants
pubmed: 30643713
doi: 10.1002/advs.201800952
pii: ADVS815
pmc: PMC6325585
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1800952Références
Nat Biomed Eng. 2017 Jan;1(1):0005
pubmed: 28480128
Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):711-30
pubmed: 20153388
Science. 2012 May 4;336(6081):604-8
pubmed: 22556257
ACS Nano. 2016 Apr 26;10(4):3881-3885
pubmed: 27077481
Nucleic Acids Res. 2013 Apr;41(7):e77
pubmed: 23355611
ACS Chem Biol. 2014 May 16;9(5):1197-203
pubmed: 24625002
Nat Commun. 2014 Nov 11;5:5392
pubmed: 25386727
J Neurosci. 2006 Oct 11;26(41):10380-6
pubmed: 17035522
Trends Microbiol. 2015 Feb;23(2):91-8
pubmed: 25432080
Nature. 2009 Sep 3;461(7260):104-8
pubmed: 19693014
Trends Biotechnol. 2017 Jul;35(7):625-639
pubmed: 28552428
PLoS One. 2013 Aug 07;8(8):e70861
pubmed: 23951027
Sci Transl Med. 2013 Mar 20;5(177):177ps5
pubmed: 23515075
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13940-5
pubmed: 14615590
Curr Opin Neurobiol. 2011 Dec;21(6):942-6
pubmed: 21708457
Nat Rev Mol Cell Biol. 2014 Aug;15(8):551-8
pubmed: 25027655
Nature. 2009 Oct 15;461(7266):997-1001
pubmed: 19749742
Nature. 2009 Apr 23;458(7241):1025-9
pubmed: 19295515
Nat Commun. 2017 Jun 23;8(1):30
pubmed: 28646204
Nat Methods. 2014 Jun;11(6):633-6
pubmed: 24793453
Nat Neurosci. 2004 Dec;7(12):1381-6
pubmed: 15558062
Nat Chem Biol. 2018 Jul;14(7):723-729
pubmed: 29686358
Genome Biol. 2016 Aug 31;17(1):183
pubmed: 27582168
Science. 2007 May 18;316(5827):1054-7
pubmed: 17510367
Nat Rev Mol Cell Biol. 2016 Jan;17(1):5-15
pubmed: 26670017
Nat Chem Biol. 2015 Dec;11(12):952-4
pubmed: 26457372
Biotechnol J. 2015 Jul;10(7):1005-18
pubmed: 26010998
FEBS Lett. 2014 Aug 1;588(15):2537-44
pubmed: 24844435
Cell. 2016 Oct 6;167(2):419-432.e16
pubmed: 27693353
Nat Methods. 2016 Jul;13(7):591-7
pubmed: 27159085
Nat Biotechnol. 2015 Oct;33(10):1092-6
pubmed: 26368050
Nat New Biol. 1971 Sep 29;233(39):149-52
pubmed: 4940442
Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6396-6419
pubmed: 27943572
Biotechnol J. 2018 May;13(5):e1700160
pubmed: 29144600
Curr Opin Biotechnol. 2017 Oct;47:59-66
pubmed: 28662442
Neuron. 2002 Jan 3;33(1):15-22
pubmed: 11779476
Genome Biol. 2005;6(3):213
pubmed: 15774036
Nucleic Acids Res. 2003 Jun 15;31(12):e69
pubmed: 12799458
Sci Am. 2010 Nov;303(5):48-55
pubmed: 21033283
Biophys Rev. 2017 Dec;9(6):861-876
pubmed: 29178082
Sci Transl Med. 2015 Dec 16;7(318):318ra201
pubmed: 26676608
Nat Protoc. 2013 Dec;8(12):2413-2428
pubmed: 24202555
Angew Chem Int Ed Engl. 2015 May 11;54(20):5933-8
pubmed: 25788334
Sci Adv. 2017 Sep 22;3(9):e1603187
pubmed: 28948217
Nat Methods. 2013 Mar;10(3):249-52
pubmed: 23377377
ACS Nano. 2016 Jan 26;10(1):225-37
pubmed: 26618393
PLoS Biol. 2015 May 07;13(5):e1002143
pubmed: 25950461
Annu Rev Biochem. 2017 Jun 20;86:845-872
pubmed: 28301742
Nat Neurosci. 2005 Sep;8(9):1263-8
pubmed: 16116447
Nat Commun. 2015 Apr 22;6:6898
pubmed: 25902152
Nat Biotechnol. 2015 Jul;33(7):755-60
pubmed: 26076431
Nat Methods. 2011 Jan;8(1):26-9
pubmed: 21191368
Nat Methods. 2011 Sep 11;8(10):837-9
pubmed: 21909100
Nat Biotechnol. 2009 Oct;27(10):941-5
pubmed: 19801976
Nat Commun. 2013;4:1779
pubmed: 23653191
Annu Rev Immunol. 2017 Apr 26;35:229-253
pubmed: 28446063
Cell. 2013 Dec 5;155(6):1422-34
pubmed: 24315106
Annu Rev Chem Biomol Eng. 2017 Jun 7;8:13-39
pubmed: 28592174
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6371-6
pubmed: 24733886
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E358-67
pubmed: 26733686
Annu Rev Physiol. 2004;66:665-88
pubmed: 14977418
Chem Biol. 2014 Jul 17;21(7):903-12
pubmed: 24981772
Curr Opin Biotechnol. 2017 Oct;47:112-119
pubmed: 28715701
Nat Chem Biol. 2018 Jun;14(6):591-600
pubmed: 29686359
Cell. 2011 Dec 23;147(7):1446-57
pubmed: 22196724
Annu Rev Plant Biol. 2011;62:515-48
pubmed: 21438681
Science. 2016 Dec 9;354(6317):1296-1301
pubmed: 27940875
Nat Commun. 2014 Sep 18;5:4925
pubmed: 25233328
Chem Rev. 2014 Jan 8;114(1):126-63
pubmed: 24364740
Curr Opin Struct Biol. 2015 Aug;33:8-15
pubmed: 26038227
Nat Methods. 2012 Mar 04;9(4):379-84
pubmed: 22388287
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8689-94
pubmed: 12060707
Nat Biotechnol. 2010 Apr;28(4):355-60
pubmed: 20351688
Trends Biotechnol. 2017 Mar;35(3):215-226
pubmed: 27692897
Nat Methods. 2012 Feb 12;9(3):266-9
pubmed: 22327833
PLoS One. 2015 Jun 17;10(6):e0128443
pubmed: 26083500
FEBS Lett. 2011 May 20;585(10):1474-84
pubmed: 21453701
Nature. 2000 Nov 9;408(6809):207-11
pubmed: 11089975
ACS Chem Biol. 2018 Feb 16;13(2):443-448
pubmed: 28938067
Chem Biol. 2015 Feb 19;22(2):169-74
pubmed: 25619936
Science. 2013 Apr 12;340(6129):211-6
pubmed: 23580530
Nat Med. 2015 Feb;21(2):121-31
pubmed: 25654603
Nat Commun. 2014 Jul 14;5:4404
pubmed: 25019686
Brain Res. 2013 May 20;1511:1-5
pubmed: 23422677
Biol Chem. 2015 Feb;396(2):145-52
pubmed: 25153239
Front Mol Biosci. 2015 May 12;2:18
pubmed: 25988185
Cell Calcium. 2017 Jun;64:36-46
pubmed: 28104276
Science. 2018 Feb 9;359(6376):
pubmed: 29439214
ACS Chem Biol. 2014 Jan 17;9(1):111-5
pubmed: 24180414
Biophys Physicobiol. 2017 Dec 19;14:183-190
pubmed: 29362703
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8174-E8183
pubmed: 28893998
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2408-12
pubmed: 17277079
PLoS One. 2012;7(1):e30774
pubmed: 22292038
Elife. 2015 Dec 08;4:
pubmed: 26646180
PLoS One. 2014 Mar 12;9(3):e91323
pubmed: 24621599
Nature. 2016 Dec 21;540(7634):S106-S108
pubmed: 28002399
Science. 2012 Nov 9;338(6108):810-4
pubmed: 23139335
Sci Transl Med. 2017 Apr 26;9(387):
pubmed: 28446682
Nat Rev Genet. 2011 Nov 29;13(1):21-35
pubmed: 22124480
Nat Nanotechnol. 2015 Nov;10(11):924-36
pubmed: 26530022
Nat Protoc. 2018 May;13(5):1121-1136
pubmed: 29700485
Crit Rev Biotechnol. 2016 Dec;36(6):1110-1122
pubmed: 26383226
Annu Rev Neurosci. 2011;34:389-412
pubmed: 21692661
ACS Synth Biol. 2012 Mar 16;1(3):75-82
pubmed: 23651071
J Biol Chem. 2011 Jan 14;286(2):1181-8
pubmed: 21030594
Gene Ther. 2015 Jul;22(7):553-9
pubmed: 25809465
Sci Rep. 2013;3:1635
pubmed: 23567447
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Chem Commun (Camb). 2013 Oct 11;49(79):8970-2
pubmed: 23963496
Curr Opin Biotechnol. 2012 Oct;23(5):695-702
pubmed: 22204821
EMBO J. 2014 Aug 1;33(15):1713-26
pubmed: 24986882
Neuron. 2016 Jun 1;90(5):1016-27
pubmed: 27181062
Chem Commun (Camb). 2017 Dec 14;53(100):13375-13378
pubmed: 29200218
Nat Protoc. 2014 Mar;9(3):622-32
pubmed: 24556785
Nat Biotechnol. 2015 Dec;33(12):1280-1286
pubmed: 26551059
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18150-5
pubmed: 24127594
Science. 2011 Jun 24;332(6037):1565-8
pubmed: 21700876
Adv Sci (Weinh). 2018 Sep 30;6(1):1800952
pubmed: 30643713
Angew Chem Int Ed Engl. 2016 May 17;55(21):6339-42
pubmed: 27101018
Trends Biotechnol. 2015 Feb;33(2):92-100
pubmed: 25529484
Sci Signal. 2011 Aug 2;4(184):ra50
pubmed: 21868352
Nat Chem Biol. 2015 Mar;11(3):198-200
pubmed: 25664691
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2853-7
pubmed: 4517939
Gastroenterology. 2012 Aug;143(2):301-6
pubmed: 22721803
Nanoscale. 2015 Oct 28;7(40):16571-7
pubmed: 26415758
Nature. 2013 Aug 22;500(7463):472-476
pubmed: 23877069
J Cell Biol. 2013 May 13;201(4):631-40
pubmed: 23671313
Nat Commun. 2015 Feb 24;6:6256
pubmed: 25708714
Int J Neuropsychopharmacol. 2015 Jul 25;18(11):pyv079
pubmed: 26209858
Mol Cell. 2014 Aug 7;55(3):397-408
pubmed: 25018017
Nat Methods. 2016 Sep;13(9):755-8
pubmed: 27427858
Nat Rev Genet. 2010 May;11(5):367-79
pubmed: 20395970