Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species.
Bartonella
Bep effector proteins
Trw
VirB/VirD4
host adaptation
type-IV-secretion systems
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
25
09
2018
revised:
17
12
2018
accepted:
06
01
2019
pubmed:
16
1
2019
medline:
19
5
2020
entrez:
16
1
2019
Statut:
ppublish
Résumé
The α-proteobacterial genus Bartonella comprises a large number of facultative intracellular pathogens that share a common lifestyle hallmarked by hemotrophic infection and arthropod transmission. Speciation in the four deep-branching lineages (L1-L4) occurred by host adaptation facilitating the establishment of long lasting bacteraemia in specific mammalian reservoir host(s). Two distinct type-IV-secretion systems (T4SSs) acquired horizontally by different Bartonella lineages mediate essential host interactions during infection and represent key innovations for host adaptation. The Trw-T4SS confined to the species-rich L4 mediates host-specific erythrocyte infection and likely has functionally replaced flagella as ancestral virulence factors implicated in erythrocyte colonisation by bartonellae of the other lineages. The VirB/VirD4-T4SS translocates Bartonella effector proteins (Bep) into various host cell types to modulate diverse cellular and innate immune functions involved in systemic spreading of bacteria following intradermal inoculation. Independent acquisition of the virB/virD4/bep locus by L1, L3, and L4 was likely driven by arthropod vectors associated with intradermal inoculation of bacteria rather than facilitating direct access to blood. Subsequently, adaptation to colonise specific niches in the new host has shaped the evolution of complex species-specific Bep repertoires. This diversification of the virulence factor repertoire of Bartonella spp. represents a remarkable example for parallel evolution of host adaptation.
Identifiants
pubmed: 30644157
doi: 10.1111/cmi.13004
pmc: PMC6519360
doi:
Substances chimiques
Type IV Secretion Systems
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13004Informations de copyright
© 2019 The Authors Cellular Microbiology Published by John Wiley & Sons Ltd.
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