Estimation of log-odds ratio from group testing data using Firth correction.
Firth correction
exposure status
maximum likelihood estimate
prevalence of a disease
sensitivity
specificity
Journal
Biometrical journal. Biometrische Zeitschrift
ISSN: 1521-4036
Titre abrégé: Biom J
Pays: Germany
ID NLM: 7708048
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
13
05
2018
revised:
07
11
2018
accepted:
09
11
2018
pubmed:
16
1
2019
medline:
6
2
2020
entrez:
16
1
2019
Statut:
ppublish
Résumé
We consider the estimation of the prevalence of a rare disease, and the log-odds ratio for two specified groups of individuals from group testing data. For a low-prevalence disease, the maximum likelihood estimate of the log-odds ratio is severely biased. However, Firth correction to the score function leads to a considerable improvement of the estimator. Also, for a low-prevalence disease, if the diagnostic test is imperfect, the group testing is found to yield more precise estimate of the log-odds ratio than the individual testing.
Identifiants
pubmed: 30645765
doi: 10.1002/bimj.201800125
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
714-728Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.