Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity.
Cisplatin
/ adverse effects
Cystathionine gamma-Lyase
/ genetics
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Hydrogen Sulfide
/ therapeutic use
Kidney
/ drug effects
Kidney Diseases
/ chemically induced
Morpholines
/ therapeutic use
Neoplasms
/ complications
Organothiophosphorus Compounds
/ therapeutic use
Oxidation-Reduction
/ drug effects
Reactive Oxygen Species
/ metabolism
Smell
/ drug effects
GYY4137
NADPH oxidase
cisplatin-induced nephrotoxicity
cystathionine γ-lyase
hydrogen polysulfide
hydrogen sulfide
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jan 2019
14 Jan 2019
Historique:
received:
16
12
2018
revised:
08
01
2019
accepted:
10
01
2019
entrez:
17
1
2019
pubmed:
17
1
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Though historically known as a toxic gas, hydrogen sulfide (H₂S) has displayed a new face as the third endogenous gaseous signaling molecule after nitric oxide (NO) and carbon monoxide (CO). Here in this review, we survey the role and therapeutic potential of H₂S in cisplatin-induced nephrotoxicity. Specifically, reduction of H₂S by cystathionine γ-lyase (CSE) downregulation upon cisplatin treatment may contribute to cisplatin-induced renal cell injury, possibly by augmentation of endogenous reactive oxygen species (ROS) production, while H₂S donation may prevent subsequent renal dysfunction by inhibiting NADPH oxidase activation. Intriguingly, H₂S slow-releasing compound GYY4137 seems to increase the anticancer activity of cisplatin, at least in several cancer cell lines, and this is probably due to its own anticancer effect. However, the efficacy of H₂S donors in tumor-bearing animals remains to be tested in terms of renal protection and cancer inhibition after receiving cisplatin. Furthermore, accumulative evidence regarding usage of polysulfide, a novel H₂S derived molecule, in the therapy of cisplatin-induced nephrotoxicity, was also summarized.
Identifiants
pubmed: 30646560
pii: ijms20020313
doi: 10.3390/ijms20020313
pmc: PMC6359127
pii:
doi:
Substances chimiques
GYY 4137
0
Morpholines
0
Organothiophosphorus Compounds
0
Reactive Oxygen Species
0
Cystathionine gamma-Lyase
EC 4.4.1.1
Cisplatin
Q20Q21Q62J
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education of Singapore
ID : Tier 2 Research grant (MOE2017-T2-2-029)
Organisme : National Medical Research Council
ID : CIRG/1432/2015
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