Growing teratoma syndrome in primary mediastinal germ cell tumor: our experience.
Antineoplastic Agents
/ adverse effects
Biomarkers, Tumor
/ blood
Biopsy
Cell Proliferation
Databases, Factual
Disease Progression
Humans
Magnetic Resonance Imaging
Male
Mediastinal Neoplasms
/ blood
Neoplasms, Germ Cell and Embryonal
/ blood
Retrospective Studies
Syndrome
Teratoma
/ blood
Testicular Neoplasms
/ blood
Thoracotomy
Tomography, X-Ray Computed
Treatment Outcome
Tumor Burden
Young Adult
Biomarkers
Mediastinal neoplasms
Neoplasms
Teratoma.
germ cell and embryonal
tumor
Journal
Asian cardiovascular & thoracic annals
ISSN: 1816-5370
Titre abrégé: Asian Cardiovasc Thorac Ann
Pays: England
ID NLM: 9503417
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
17
1
2019
medline:
10
4
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. It has been found in various locations, most commonly, the retroperitoneum in association with metastatic disease. The occurrence of growing teratoma syndrome in a mediastinal primary is very rare and there are only a few reports in the literature. In a retrospective review, out of 12 patients with mediastinal involvement by a germ cell tumor, 5 had a primary from the mediastinum. We present a series of 3 cases of primary germ cell tumor of the mediastinum, which after chemotherapy, fulfilled the criteria for growing teratoma syndrome and were managed with surgical excision. Development of growing teratoma syndrome in a primary mediastinal germ cell tumor is extremely rare. Its awareness and early detection can lead to successful surgical excision and long-term cure.
Sections du résumé
BACKGROUND
BACKGROUND
Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. It has been found in various locations, most commonly, the retroperitoneum in association with metastatic disease. The occurrence of growing teratoma syndrome in a mediastinal primary is very rare and there are only a few reports in the literature.
METHODS
METHODS
In a retrospective review, out of 12 patients with mediastinal involvement by a germ cell tumor, 5 had a primary from the mediastinum. We present a series of 3 cases of primary germ cell tumor of the mediastinum, which after chemotherapy, fulfilled the criteria for growing teratoma syndrome and were managed with surgical excision.
CONCLUSION
CONCLUSIONS
Development of growing teratoma syndrome in a primary mediastinal germ cell tumor is extremely rare. Its awareness and early detection can lead to successful surgical excision and long-term cure.
Identifiants
pubmed: 30646758
doi: 10.1177/0218492318823345
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers, Tumor
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM