An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children.


Journal

Italian journal of pediatrics
ISSN: 1824-7288
Titre abrégé: Ital J Pediatr
Pays: England
ID NLM: 101510759

Informations de publication

Date de publication:
15 Jan 2019
Historique:
received: 22 10 2018
accepted: 03 01 2019
entrez: 17 1 2019
pubmed: 17 1 2019
medline: 22 5 2019
Statut: epublish

Résumé

Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10-15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12.1, 17q12, 6p12.2 and 17q21.1, identifying possible candidate genes responsible for susceptibility to asthma and rhino-conjunctivitis.

Identifiants

pubmed: 30646946
doi: 10.1186/s13052-019-0603-4
pii: 10.1186/s13052-019-0603-4
pmc: PMC6334451
doi:

Types de publication

Letter

Langues

eng

Sous-ensembles de citation

IM

Pagination

16

Subventions

Organisme : Regional Agency for Environment Protection (ARPA Sicilia)
ID : DDG No. 303/2005

Références

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Auteurs

Gianluca Sottile (G)

Department of Economics, Business and Statistical Science, University of Palermo, Viale delle Scienze, Building 13, 90128, Palermo, Italy. gianluca.sottile@unipa.it.

Giuliana Ferrante (G)

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.

Marta Torregrossa (M)

National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

Fabio Cibella (F)

National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

Giovanna Cilluffo (G)

National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

Salvatore Fasola (S)

National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

Riccardo Alessandro (R)

National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.
Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata, University of Palermo, Palermo, Italy.

Gregorio Seidita (G)

Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata, University of Palermo, Palermo, Italy.

Giovanni Viegi (G)

National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.
National Research Council of Italy, Institute of Clinical Physiology, Pisa, Italy.

Stefania La Grutta (S)

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.
National Research Council of Italy, Institute of Biomedicine and Molecular Immunology, Palermo, Italy.

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Classifications MeSH