Mechanisms of antibiotics inhibiting bacterial RNA polymerase.
RNA polymerase
antibiotic resistance
antibiotics
mechanism of action of antibiotics
rifampicin
transcription
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
28 02 2019
28 02 2019
Historique:
received:
29
10
2018
revised:
18
12
2018
accepted:
20
12
2018
pubmed:
17
1
2019
medline:
1
5
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
Transcription, the first phase of gene expression, is performed by the multi-subunit RNA polymerase (RNAP). Bacterial RNAP is a validated target for clinical antibiotics. Many natural and synthetic compounds are now known to target RNAP, inhibiting various stages of the transcription cycle. However, very few RNAP inhibitors are used clinically. A detailed knowledge of inhibitors and their mechanisms of action (MOA) is vital for the future development of efficacious antibiotics. Moreover, inhibitors of RNAP are often useful tools with which to dissect RNAP function. Here, we review the MOA of antimicrobial transcription inhibitors.
Identifiants
pubmed: 30647141
pii: BST20180499
doi: 10.1042/BST20180499
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Enzyme Inhibitors
0
DNA-Directed RNA Polymerases
EC 2.7.7.6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
339-350Informations de copyright
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.