Neurons in FEF Keep Track of Items That Have Been Previously Fixated in Free Viewing Visual Search.
eye movement
frontal eye field
inhibition of return
inhibitory tagging
putative tracking neurons
visual search
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
13 03 2019
13 03 2019
Historique:
received:
13
07
2018
revised:
30
11
2018
accepted:
02
12
2018
pubmed:
17
1
2019
medline:
17
3
2020
entrez:
17
1
2019
Statut:
ppublish
Résumé
When searching a visual scene for a target, we tend not to look at items or locations we have already searched. It is thought that this behavior is driven by an inhibitory tagging mechanism that inhibits responses on priority maps to the relevant items. We hypothesized that this inhibitory tagging signal should be represented as an elevated response in neurons that keep track of stimuli that have been fixated. We recorded from 231 neurons in the frontal eye field (FEF) of 2 male animals performing a visual foraging task, in which they had to find a reward linked to one of five identical targets (Ts) among five distractors. We identified 38 neurons with activity that was significantly greater when the stimulus in the receptive field had been fixated previously in the trial than when it had not been fixated. The response to a fixated object began before the saccade ended, suggesting that this information is remapped. Unlike most FEF neurons, the activity in these cells was not suppressed during active fixation, had minimal motor responses, and did not change through the trial. Yet using traditional classifications from a memory-guided saccade, they were indistinguishable from the rest of the FEF population. We propose that these neurons keep track of any items that have been fixated within the trial and this signal is propagated by remapping. These neurons could be the source of the inhibitory tagging signal to parietal cortex, where a neuronal instantiation of inhibitory tagging is seen.
Identifiants
pubmed: 30647149
pii: JNEUROSCI.1767-18.2018
doi: 10.1523/JNEUROSCI.1767-18.2018
pmc: PMC6507089
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2114-2124Subventions
Organisme : NEI NIH HHS
ID : R01 EY019273
Pays : United States
Informations de copyright
Copyright © 2019 the authors 0270-6474/19/392114-11$15.00/0.
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