Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps.


Journal

Tissue engineering. Part C, Methods
ISSN: 1937-3392
Titre abrégé: Tissue Eng Part C Methods
Pays: United States
ID NLM: 101466663

Informations de publication

Date de publication:
02 2019
Historique:
pubmed: 17 1 2019
medline: 4 1 2020
entrez: 17 1 2019
Statut: ppublish

Résumé

The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between fibrosis and regeneration as a function of injury size in the mouse quadriceps. There is currently limited understanding of what leads to a critically sized muscle defect and which muscle regenerative components are functionally impaired. With the substantial increase in preclinical VML models as testbeds for tissue engineering therapeutics, defining the critical threshold for VML injuries will be instrumental in characterizing therapeutic efficacy and potential for subsequent translation.

Identifiants

pubmed: 30648479
doi: 10.1089/ten.TEC.2018.0324
pmc: PMC6389771
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

59-70

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR062920
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR072287
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008433
Pays : United States

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Auteurs

Shannon E Anderson (SE)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Woojin M Han (WM)

2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
3 George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia.

Vunya Srinivasa (V)

2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
4 School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.

Mahir Mohiuddin (M)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Marissa A Ruehle (MA)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

June Young Moon (JY)

2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
4 School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.

Eunjung Shin (E)

2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
4 School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.

Cheryl L San Emeterio (CL)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Molly E Ogle (ME)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Edward A Botchwey (EA)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Nick J Willett (NJ)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
5 Department of Orthopedics, Emory University, Atlanta, Georgia.
6 Atlanta Veteran's Affairs Medical Center, Decatur, Georgia.

Young C Jang (YC)

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory Unversity, Atlanta, Georgia.
2 Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.
4 School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia.

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Classifications MeSH