Functional Cortical Axon Tracts Generated from Human Stem Cell-Derived Neurons.
axons
cortical neuron differentiation
neuronal network
stem cells
tissue engineering
Journal
Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
17
1
2019
medline:
31
12
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
Axon regeneration is negligible in the adult mammalian brain, and thus, white matter damage often leads to permanent neurological deficits. A novel approach for axon repair is the generation of axon tracts in the laboratory setting followed by transplantation of these constructs. This article details a human substrate for this repair strategy. Using the technique of axon stretch growth, functional cortical axon tracts are generated from human pluripotent stem cells at rates of up to 1 mm/day. These results form the basis of a potential patient-specific protocol for cerebral axon transplantation after injury.
Identifiants
pubmed: 30648482
doi: 10.1089/ten.TEA.2018.0270
pmc: PMC6535960
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
736-745Subventions
Organisme : NINDS NIH HHS
ID : F32 NS073267
Pays : United States
Organisme : RRD VA
ID : IK2 RX002013
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092398
Pays : United States
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