Associations of metabolically healthy obesity with prevalence and progression of coronary artery calcification: Results from the Heinz Nixdorf Recall Cohort Study.
Aged
Computed Tomography Angiography
Coronary Angiography
/ methods
Coronary Artery Disease
/ diagnostic imaging
Cross-Sectional Studies
Disease Progression
Female
Germany
/ epidemiology
Humans
Longitudinal Studies
Male
Middle Aged
Obesity, Metabolically Benign
/ diagnosis
Prevalence
Prognosis
Prospective Studies
Risk Factors
Time Factors
Vascular Calcification
/ diagnostic imaging
Cohort study
Coronary artery calcification
Coronary artery calcium
Metabolic syndrome
Metabolically healthy obesity
Subclinical atherosclerosis
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
27
08
2018
revised:
02
11
2018
accepted:
07
11
2018
pubmed:
17
1
2019
medline:
18
12
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
There is controversy on the potentially benign nature of metabolically healthy obesity (MHO), i.e., obese persons with few or no metabolic abnormalities. So far, associations between MHO and coronary artery calcification (CAC), a measure of subclinical atherosclerosis, have mainly been studied cross-sectionally in Asian populations. We assessed cross-sectional and longitudinal MHO CAC associations in a Caucasian population. In the Heinz Nixdorf Recall Study, a population-based cohort study in Germany, CAC was assessed by electron-beam tomography at baseline and at 5-year follow-up. For cross-sectional and longitudinal analyses, we included 1585 participants free of coronary heart disease at baseline, with CAC measurements at baseline and at follow-up, and with either normal weight (BMI 18.5-24.9 kg/m Our analyses on MHO CAC associations add to the evidence that MHO is not a purely benign health condition.
Sections du résumé
BACKGROUND AND AIMS
There is controversy on the potentially benign nature of metabolically healthy obesity (MHO), i.e., obese persons with few or no metabolic abnormalities. So far, associations between MHO and coronary artery calcification (CAC), a measure of subclinical atherosclerosis, have mainly been studied cross-sectionally in Asian populations. We assessed cross-sectional and longitudinal MHO CAC associations in a Caucasian population.
METHODS AND RESULTS
In the Heinz Nixdorf Recall Study, a population-based cohort study in Germany, CAC was assessed by electron-beam tomography at baseline and at 5-year follow-up. For cross-sectional and longitudinal analyses, we included 1585 participants free of coronary heart disease at baseline, with CAC measurements at baseline and at follow-up, and with either normal weight (BMI 18.5-24.9 kg/m
CONCLUSION
Our analyses on MHO CAC associations add to the evidence that MHO is not a purely benign health condition.
Identifiants
pubmed: 30648599
pii: S0939-4753(18)30329-6
doi: 10.1016/j.numecd.2018.11.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-235Informations de copyright
Copyright © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.