RNF216 is essential for spermatogenesis and male fertility†.
Journal
Biology of reproduction
ISSN: 1529-7268
Titre abrégé: Biol Reprod
Pays: United States
ID NLM: 0207224
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
06
09
2018
revised:
12
12
2018
accepted:
14
01
2019
pubmed:
17
1
2019
medline:
10
6
2020
entrez:
17
1
2019
Statut:
ppublish
Résumé
Ring finger protein 216 (RNF216) belongs to the RING family of E3 ubiquitin ligases that are involved in cellular protein degradation. Mutations in human Rnf216 gene have been identified in Gordon Holmes syndrome, which is defined by ataxia, dementia, and hypogonadotropism. However, the gene function of Rnf216 in mammalian species remains unknown. Here, we show that targeted deletion of Rnf216 in mice results in disruption in spermatogenesis and male infertility. RNF216 is not required for female fertility. These findings reveal an essential function of RNF216 in spermatogenesis and male fertility and suggest a critical role for RNF216 in human gonadal development.
Identifiants
pubmed: 30649198
pii: 5289569
doi: 10.1093/biolre/ioz006
pmc: PMC6698654
doi:
Substances chimiques
RNF216 protein, human
EC 2.3.2.27
RNF216 protein, mouse
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1132-1134Subventions
Organisme : NICHD NIH HHS
ID : R01 HD084494
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.
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