Of Aging Mice and Men: Gait Speed Decline Is a Translatable Trait, With Species-Specific Underlying Properties.
Biomarker
Cadence
Cross-species comparison
Healthspan
Step length
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
16 08 2019
16 08 2019
Historique:
received:
11
12
2018
accepted:
11
01
2019
pubmed:
17
1
2019
medline:
12
6
2020
entrez:
17
1
2019
Statut:
ppublish
Résumé
In the last two decades, great strides were made in our ability to extend the life span of model organisms through dietary and other manipulations. Survival curves provide evidence of altered aging processes but are uninformative on what lead to that increase in life span. Longitudinal assessments of health and function during intervention studies could help in the identification of predictive biomarkers for health and survival. Comparable biomarkers of healthspan are necessary to effectively translate interventions into human clinical trials. Gait speed is a well-established predictive biomarker of healthspan in humans for risk of disability, health outcomes and mortality, and is relatively simple to assess noninvasively in rodents. In this study, we assessed and compared gait speed in males from two species (mice and humans), from young adulthood to advanced old age. Although gait speed decreases nonlinearly with age in both species, the underlying drivers of this change in gait speed were different, with humans exhibiting a shortened step length, and mice displaying a decrease in cadence. Future longitudinal and interventional studies in mice should examine the predictive value of longitudinal declines in gait speed for health and survival.
Identifiants
pubmed: 30649206
pii: 5289189
doi: 10.1093/gerona/glz015
pmc: PMC6696716
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1413-1416Informations de copyright
Published by Oxford University Press on behalf of The Gerontological Society of America 2019.
Références
J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):M221-31
pubmed: 10811152
Aging (Albany NY). 2016 Oct 2;8(10):2370-2391
pubmed: 27705904
J Am Geriatr Soc. 2007 Nov;55(11):1727-34
pubmed: 17916121
Physiol Behav. 2009 Feb 16;96(2):350-61
pubmed: 19027767
J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1184-94
pubmed: 26975983
Age (Dordr). 2014 Apr;36(2):583-92
pubmed: 24122289
J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1304-9
pubmed: 16282564
Science. 1974 Dec 20;186(4169):1112-3
pubmed: 4469699
JAMA Cardiol. 2016 Jun 1;1(3):314-21
pubmed: 27438112
J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):209-12
pubmed: 19196900
Neurobiol Aging. 2011 Oct;32(10):1868-80
pubmed: 20005598
J Rehabil Res Dev. 2005 Jul-Aug;42(4):535-46
pubmed: 16320148
Gerontology. 1996;42(1):7-13
pubmed: 8641604
J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):63-71
pubmed: 26297942
Arch Neurol. 2002 Apr;59(4):601-6
pubmed: 11939895
Physiotherapy. 2015 Sep;101(3):266-72
pubmed: 25702092
Cell Metab. 2016 Jun 14;23(6):1093-1112
pubmed: 27304509
Arch Intern Med. 2012 Feb 27;172(4):353-8
pubmed: 22371922
J Neurosci Methods. 1997 Jul 18;75(1):49-54
pubmed: 9262143
J Am Geriatr Soc. 2005 Oct;53(10):1675-80
pubmed: 16181165
JAMA. 2011 Jan 5;305(1):50-8
pubmed: 21205966
J Gerontol. 1966 Oct;21(4):575-80
pubmed: 5918312
J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1243-53
pubmed: 25910845