Immunodeficiencies that predispose to pathologies by human oncogenic γ-herpesviruses.
Burkitt's lymphoma
Epstein Barr virus
Hodgkin's lymphoma
Kaposi sarcoma
Kaposi sarcoma-associated herpesvirus
hemophagocytic lymphohistiocytosis
primary effusion lymphoma
Journal
FEMS microbiology reviews
ISSN: 1574-6976
Titre abrégé: FEMS Microbiol Rev
Pays: England
ID NLM: 8902526
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
10
09
2018
accepted:
30
11
2018
pubmed:
17
1
2019
medline:
27
4
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
Human γ-herpesviruses include the closely related tumor viruses Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV). EBV is the most growth-transforming pathogen known and is linked to at least seven human malignancies. KSHV is also associated with three human cancers. Most EBV- and KSHV-infected individuals fortunately remain disease-free despite persistent infection and this is likely due to the robustness of the immune control that they mount against these tumor viruses. However, upon immune suppression EBV- and KSHV-associated malignancies emerge at increased frequencies. Moreover, primary immunodeficiencies with individual mutations that predispose to EBV or KSHV disease allow us to gain insights into a catalog of molecules that are required for the immune control of these tumor viruses. Curiously, there is little overlap between the mutation targets that predispose individuals to EBV versus KSHV disease, even so both viruses can infect the same host cell, human B cells. These differences will be discussed in this review. A better understanding of the crucial components in the near-perfect life-long immune control of EBV and KSHV should allow us to target malignancies that are associated with these viruses, but also induce similar immune responses against other tumors.
Identifiants
pubmed: 30649299
pii: 5289573
doi: 10.1093/femsre/fuy044
pmc: PMC6435449
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-192Informations de copyright
© FEMS 2019.
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