Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome.
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
26
09
2018
accepted:
08
01
2019
pubmed:
17
1
2019
medline:
28
4
2020
entrez:
17
1
2019
Statut:
ppublish
Résumé
Normal-weight women with polycystic ovary syndrome (PCOS) may have adipose tissue insulin resistance (adipose-IR). To examine whether adipose-IR and subcutaneous (SC) abdominal adipose stem cell (ASC) gene expression are altered in normal-weight women with PCOS and correlated with hyperandrogenemia and/or whole-body IR. Prospective cohort study. Academic medical center. Ten normal-weight women with PCOS and 18 control subjects matched for age and body mass index. Women underwent circulating hormone and metabolic measurements, IV glucose tolerance testing, total-body dual-energy x-ray absorptiometry, and SC abdominal fat biopsy. Adipose-IR (fasting insulin × total fatty acid levels) and SC abdominal ASC gene expression were compared between groups and correlated with clinical outcomes. Adipose-IR was greater in women with PCOS than in control subjects (P < 0.01), with 29 pmol/L × mmol/L providing 94% specificity and 80% sensitivity in discriminating the two groups (P < 0.001). Adipose-IR positively correlated with serum androgen and log of fasting triglyceride (TG) levels, percentage of small adipocytes (P < 0.01, all correlations), and acute insulin response to glucose (P < 0.05); and negatively correlated with insulin sensitivity (Si; P < 0.025) and serum adiponectin levels (P < 0.05). Adjusting for serum androgens, adipose-IR correlations with Si and log TG levels remained significant. ASC genes were differentially expressed by the two groups. Expression of functionally critical genes was associated with serum testosterone and/or fasting insulin levels. Normal-weight women with PCOS have increased adipose-IR and altered ASC gene expression related to hyperandrogenism and IR.
Identifiants
pubmed: 30649347
pii: 5288014
doi: 10.1210/jc.2018-02086
pmc: PMC6482023
doi:
Substances chimiques
ADIPOQ protein, human
0
Adiponectin
0
Transforming Growth Factor beta
0
Triglycerides
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2171-2183Subventions
Organisme : NICHD NIH HHS
ID : P50 HD071836
Pays : United States
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Informations de copyright
Copyright © 2019 Endocrine Society.
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