Resistin: A reappraisal.
Aged
Aging
/ genetics
Animals
Cardiovascular Diseases
/ mortality
Central Nervous System Diseases
/ physiopathology
Chronic Disease
Glucose
/ metabolism
Humans
Inflammation
/ genetics
Insulin Resistance
/ physiology
Mental Disorders
/ physiopathology
Mice
Middle Aged
Musculoskeletal Diseases
/ physiopathology
Obesity
/ physiopathology
Resistin
/ genetics
Adipokines
Aging
Alzheimer’s disease
Metabolism
Resistin
Journal
Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
08
08
2018
revised:
28
12
2018
accepted:
11
01
2019
pubmed:
17
1
2019
medline:
8
6
2019
entrez:
17
1
2019
Statut:
ppublish
Résumé
From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases. Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.
Identifiants
pubmed: 30650338
pii: S0047-6374(18)30168-4
doi: 10.1016/j.mad.2019.01.004
pii:
doi:
Substances chimiques
Resistin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-63Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.