Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.
CNS infection
biomarker
cerebrospinal fluid
enterovirus
meningitis
metabolomics
phosphatidylcholines
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
received:
22
12
2018
revised:
09
01
2019
accepted:
10
01
2019
entrez:
18
1
2019
pubmed:
18
1
2019
medline:
30
4
2019
Statut:
epublish
Résumé
Enteroviruses are among the most common causes of viral meningitis. Enteroviral meningitis continues to represent diagnostic challenges, as cerebrospinal fluid (CSF) cell numbers (a well validated diagnostic screening tool) may be normal in up to 15% of patients. We aimed to identify potential CSF biomarkers for enteroviral meningitis, particularly for cases with normal CSF cell count. Using targeted liquid chromatography-mass spectrometry, we determined metabolite profiles from patients with enteroviral meningitis (
Identifiants
pubmed: 30650575
pii: ijms20020337
doi: 10.3390/ijms20020337
pmc: PMC6359617
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Helmholtz Association
ID : iMed Initiative on Personalized Medicine
Organisme : Deutsche Forschungsgemeinschaft
ID : Cluster of Excelence RESIST
Organisme : Medizinischen Hochschule Hannover
ID : Junge Akademie
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